6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate hydrochloride

Base Information

• Chemical Name: 6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate hydrochloride
• CAS No.: 1216659-29-8
• Molecular Formula: C16H16Cl2N6O3
• Molecular Weight: 411.24264
• Mol file: 1216659-29-8.mol

Synonyms:6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate hydrochloride

Chemical Property of 6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate hydrochloride

Chemical Property:

• PSA: 100.55000
• LogP: 2.35950
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

N-DesmethylZopicloneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: A metabolite of Zopiclone (Z700500).

Technology Process of 6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate hydrochloride

There total 2 articles about 6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperazine-1,4-dicarboxylic acid 1-chloro-ethyl ester 6-(5-chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl ester → (S)-desmethylzopiclone hydrochloride (1216659-29-8,300701-71-7)

Guidance literature:

With methanol; In acetonitrile; Heating;

DOI:10.1016/S0957-4166(00)00455-9

Reference yield:

eszopiclone (138729-47-2) → (S)-desmethylzopiclone hydrochloride (1216659-29-8,300701-71-7)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 80 - 83 °C

2: MeOH / acetonitrile / Heating

With methanol; In acetonitrile;

DOI:10.1016/S0957-4166(00)00455-9

upstream raw materials:

eszopiclone

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