1,4-PREGNADIEN-17,20-BETA, 21-TRIOL-3,11-DIONE

Base Information

• Chemical Name: 1,4-PREGNADIEN-17,20-BETA, 21-TRIOL-3,11-DIONE
• CAS No.: 600-92-0
• Molecular Formula: C21H28O5
• Molecular Weight: 360.45
• Mol file: 600-92-0.mol

Synonyms:20-BETA-DIHYDROPREDNISONE;1,4-PREGNADIEN-17,20-BETA, 21-TRIOL-3,11-DIONE;17,20,21-Trihydroxypregna-1,4-diene-3,11-dione

Chemical Property of 1,4-PREGNADIEN-17,20-BETA, 21-TRIOL-3,11-DIONE

Chemical Property:

• PSA: 94.83000
• LogP: 1.55760
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly), Dioxane (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

98%min ^*data from raw suppliers

20β-HydroxyPrednisone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-PREGNADIEN-17,20-BETA, 21-TRIOL-3,11-DIONE

There total 5 articles about 1,4-PREGNADIEN-17,20-BETA, 21-TRIOL-3,11-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

Cortisone (53-06-5) → Prednison (53-03-2) + 17α,20β,21-trihydroxy-1,4-pregnadiene-3,11-dione (600-92-0)

Guidance literature:

With Rhodococcus rhodnii DSM 43960; In dimethyl sulfoxide; for 24h; Green chemistry; Enzymatic reaction;

DOI:10.3390/molecules26051352

Reference yield:

Prednison (53-03-2) → 17α,20β,21-trihydroxy-1,4-pregnadiene-3,11-dione (600-92-0)

Guidance literature:

With sodium tetrahydroborate;

Reference yield:

Cortisone (53-06-5) → 17α,20β,21-trihydroxy-1,4-pregnadiene-3,11-dione (600-92-0)

Guidance literature:

With calonectria decora;

upstream raw materials:

Cortisone

Prednison

17α,20β,21-trihydroxy-pregn-4-ene-3,11-dione

Downstream raw materials:

11β,17α,20β,21-tetrahydroxy-1,4-pregnadiene-3-one

Refernces