2-Ethyl-5-Methylbenzoxazole

Base Information

• Chemical Name: 2-Ethyl-5-Methylbenzoxazole
• CAS No.: 20514-29-8
• Molecular Formula: C10H11NO
• Molecular Weight: 161.20044
• Hs Code.: 2934999090
• Mol file: 20514-29-8.mol

Synonyms:2-Ethyl-5-Methylbenzoxazole

Chemical Property of 2-Ethyl-5-Methylbenzoxazole

Chemical Property:

• PSA: 26.03000
• LogP: 2.69860

Purity/Quality:

97% ^*data from raw suppliers

2-Ethyl-5-methylbenzoxazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Ethyl-5-Methylbenzoxazole

There total 5 articles about 2-Ethyl-5-Methylbenzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-amino-4-hydroxytoluene (95-84-1) + Triethyl orthopropionate (115-80-0) → 2-ethyl-5-methylbenzo[d]oxazole (20514-29-8)

Guidance literature:

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; at 20 ℃; for 0.1h;

DOI:10.1007/s00706-010-0412-3

Reference yield: 91.0%

3-amino-4-hydroxytoluene (95-84-1) + 3,5-heptanedione (7424-54-6) → 2-ethyl-5-methylbenzo[d]oxazole (20514-29-8)

Guidance literature:

With montmorillonite KSF clay; In acetonitrile; at 90 ℃; for 14h; Green chemistry;

DOI:10.1080/00397911.2019.1665183

Reference yield: 88.0%

3-amino-4-hydroxytoluene (95-84-1) + Triethyl orthopropionate (115-80-0) → 2-ethyl-5-methylbenzo[d]oxazole (20514-29-8)

Guidance literature:

With tungstate sulfuric acid; In neat (no solvent); at 80 - 90 ℃; for 0.2h; Reagent/catalyst;

DOI:10.1016/j.crci.2013.03.009

upstream raw materials:

(2-hydroxy-5-methyl)propiophenone oxime

3-amino-4-hydroxytoluene

Triethyl orthopropionate

3,5-heptanedione

Refernces

• 1、 Aksenov, Nicolai A.,Aksenov, Alexander V.,Nadein, Oleg N.,Aksenov, Dmitrii A.,Smirnov, Alexander N.,Rubin, Michael. "One-pot synthesis of benzoxazoles via the metal-free ortho-C-H functionalization of phenols with nitroalkanes". . p. 71620 - 71626. Retrieved 2015/09/08.
• 2、 Mayo, Muhammad Shareef,Yu, Xiaoqiang,Zhou, Xiaoyu,Feng, Xiujuan,Yamamoto, Yoshinori,Bao, Ming. "Synthesis of benzoxazoles from 2-aminophenols and β-diketones using a combined catalyst of br?nsted acid and copper iodide". . p. 6310 - 6314. Retrieved 2014/07/21.