(5α)-8,9-Didehydro-6,8-dimethylergoline

Base Information Edit

Chemical Name:(5α)-8,9-Didehydro-6,8-dimethylergoline
CAS No.:194346-16-2
Molecular Formula:C16H18N2
Molecular Weight:238.33
Hs Code.:
Mol file:194346-16-2.mol

Synonyms:(5α)-8,9-Didehydro-6,8-dimethylergoline;(5α,10α)-8,9-Didehydro-6,8-dimethylergoline

Suppliers and Price of (5α)-8,9-Didehydro-6,8-dimethylergoline

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5α)-8,9-Didehydro-6,8-dimethylergoline Edit

Chemical Property:

PSA：0.00000
LogP:0.00000

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5α)-8,9-Didehydro-6,8-dimethylergoline

There total 86 articles about (5α)-8,9-Didehydro-6,8-dimethylergoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1150-44-3,11012-16-1
Isochanoclavin-(I)

: 548-42-5,194346-16-2
agroclavine

Guidance literature:: With potassium carbonate; trichlorophosphate; In acetonitrile;
DOI:10.3987/COM-97-7821

Reference yield: 52.0%

: 120408-46-0
HCl salt of N-p-Ts lysergene

: 548-42-5,194346-16-2
agroclavine

Guidance literature:: ammonia; lithium;
DOI:10.1016/S0040-4039(00)84824-8

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 548-42-5,194346-16-2
agroclavine

Guidance literature:: Multi-step reaction with 12 steps

1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; copper diacetate / 4 h / 110 °C / Inert atmosphere

2: dmap / acetonitrile / 0.5 h / 40 °C

3: ammonium acetate / 2 h / 70 °C

4: diisobutylaluminium hydride / tetrahydrofuran; hexane / 1 h / -78 °C

5: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 20 °C

6: triethylamine / dichloromethane / 1 h / 0 - 20 °C

7: potassium carbonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); palladium diacetate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

8: hydrogenchloride; zinc / methanol; water / 1 h

9: potassium carbonate / acetonitrile / 20 h / 20 °C

10: triethylamine / dichloromethane / 24 h / 20 °C

11: 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(iso-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methylene ruthenium(II) dichloride / toluene / 12 h / 80 °C / Inert atmosphere

12: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Reflux

With hydrogenchloride; dmap; sodium tetrahydroborate; silver hexafluoroantimonate; lithium aluminium tetrahydride; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(iso-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methylene ruthenium(II) dichloride; ammonium acetate; copper diacetate; palladium diacetate; diisobutylaluminium hydride; potassium carbonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); triethylamine; zinc; In tetrahydrofuran; methanol; hexane; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/acs.orglett.7b01681