2,6-dichloro-N-p-tolylbenzenaMine

Base Information

• Chemical Name: 2,6-dichloro-N-p-tolylbenzenaMine
• CAS No.: 332903-73-8
• Molecular Formula: C13H11Cl2N
• Molecular Weight: 252.143
• Mol file: 332903-73-8.mol

Synonyms:2,6-dichloro-N-p-tolylbenzenaMine

Chemical Property of 2,6-dichloro-N-p-tolylbenzenaMine

Chemical Property:

• PSA: 12.03000
• LogP: 5.11840

Purity/Quality:

97-99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-dichloro-N-p-tolylbenzenaMine

There total 4 articles about 2,6-dichloro-N-p-tolylbenzenaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H13Cl2N → N-(2',6'-Dichlorophenyl)-4-methylaniline (332903-73-8)

Guidance literature:

With iodine; acetic acid; In tetrahydrofuran; chlorobenzene; at -35 - 25 ℃; for 41h;

Reference yield:

2-(2,6-dichloro-phenoxy)-N-p-tolyl-acetamide (1002502-24-0) → N-(2',6'-Dichlorophenyl)-4-methylaniline (332903-73-8)

Guidance literature:

With sodium methylate; In methanol; at 85 ℃; for 2h;

DOI:10.1016/j.tet.2004.09.064

Reference yield:

2,6-Dichlorophenol (87-65-0) → N-(2',6'-Dichlorophenyl)-4-methylaniline (332903-73-8)

Guidance literature:

Multi-step reaction with 2 steps

1: propan-2-ol / Heating

2: MeONa / methanol / 2 h / 85 °C

With sodium methylate; In methanol; isopropyl alcohol;

DOI:10.1016/j.tet.2004.09.064

upstream raw materials:

2-(2,6-dichloro-phenoxy)-N-p-tolyl-acetamide

2,6-Dichlorophenol

N-(p-tolyl)-2-chloroacetamide

Downstream raw materials:

2-chloro-N-(2',6'-dichloro-phenyl)-N-p-tolyl-acetamide

Refernces

• 1、 Acemoglu, Murat,Allmendinger, Thomas,Calienni, John,Cercus, Jacques,Loiseleur, Olivier,Sedelmeier, Gottfried H.,Xu, David. "Synthesis of new N-aryl oxindoles as intermediates for pharmacologically active compounds". . p. 11571 - 11586. Retrieved 2007/10/03.