4-CHLORO-3-IODOBENZALDOXIME

Base Information

• Chemical Name: 4-CHLORO-3-IODOBENZALDOXIME
• CAS No.: 914106-25-5
• Molecular Formula: C7H5ClINO
• Molecular Weight: 281.48
• Mol file: 914106-25-5.mol

Synonyms:4-CHLORO-3-IODOBENZALDOXIME

Chemical Property of 4-CHLORO-3-IODOBENZALDOXIME

Chemical Property:

• PSA: 32.59000
• LogP: 2.75270

Purity/Quality:

99% ^*data from raw suppliers

(E)-N-[(4-CHLORO-3-IODOPHENYL)METHYLIDENE]HYDROXYLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-3-IODOBENZALDOXIME

There total 1 articles about 4-CHLORO-3-IODOBENZALDOXIME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-chloro-3-iodobenzaldehyde (276866-90-1) → 4-chloro-3-iodobenzaldoxime (914106-25-5)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol;

DOI:10.1021/jm0612867

Reference yield: 91.0%

4-chloro-3-iodobenzaldoxime (914106-25-5) → 4-chloro-3-iodobenzonitrile (914106-26-6)

Guidance literature:

With acetic anhydride; for 4h; Heating;

DOI:10.1021/jm0612867

Reference yield:

4-chloro-3-iodobenzaldoxime (914106-25-5) → 3-(4-cyanophenyl)-5-(2-chloro-5-cyanophenyl)isoxazole (914106-16-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 91 percent / Ac₂O / 4 h / Heating

2: 88 percent / Et₃N / PdCl₂(PPh₃)2; CuI / 3 h / 60 °C

3: 62 percent / aq. cesium carbonate / acetonitrile / 120 h / 0 °C

4: 32 percent / bis(tributyltin) oxide / CH₂Cl₂

With acetic anhydride; caesium carbonate; triethylamine; bis(tri-n-butyltin)oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane; acetonitrile;

DOI:10.1021/jm0612867

upstream raw materials:

4-chloro-3-iodobenzaldehyde

Downstream raw materials:

4-chloro-3-iodobenzonitrile

4-chloro-4-[2-(trimethylsilyl)ethynyl]benzonitrile

4-chloro-3-(3-hydroxy-3-methylbut-1-ynyl)benzonitrile

4-chloro-3-ethynylbenzonitrile