Peficitinib

Base Information

• Chemical Name: Peficitinib
• CAS No.: 944118-01-8
• Molecular Formula: C₁₈H₂₂N₄O₂
• Molecular Weight: 326.398
• Mol file: 944118-01-8.mol

Synonyms:Peficitinib;4-[(trans-5-Hydroxyadamantan-2-yl)amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide;Peficitinib (ASP015K, JNJ-54781532);Carotegrast methyl

Chemical Property of Peficitinib

Chemical Property:

• PSA: 105.02000
• LogP: 2.97050
• Solubility.: Soluble in DMSO

Purity/Quality:

99% ^*data from raw suppliers

Peficitinib ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Peficitinib can be used in therapeutic use and biological study of codrug and preparation of bicyclic-fused heteroaryl or aryl compounds as IRAK4 modulators.

Technology Process of Peficitinib

There total 7 articles about Peficitinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxamide (920966-13-8) + (1u202fs,3R,4s,5S,7s)-4-aminoadamantan-1-ol (62058-03-1,62058-13-3) → 4-{[(1R,2s,3S,5s,7s)-5-hydroxy-2-adamantyl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide (944118-01-8)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; tributyl-amine; at 200 ℃; for 2.5h; Inert atmosphere;

DOI:10.1016/j.bmc.2018.08.005

Reference yield: 49.0%

4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxamide (920966-13-8) + (1u202fs,3R,4r,5S,7s)-4-aminoadamantan-1-ol (62058-13-3) → 4-{[(1R,2r,3S,5s,7s)-5-hydroxyadamantan-2-yl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide (944118-01-8)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; tributyl-amine; at 200 ℃; for 2.5h; Inert atmosphere;

DOI:10.1016/j.bmc.2018.08.005

Reference yield:

(1s,3R,4s,5S)-4-aminoadamantan-1-ol (62058-13-3) + 4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxamide (920966-13-8) → 4-{[(1R,2s,3S,5s,7s)-5-hydroxy-2-adamantyl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide (944118-01-8)

Guidance literature:

With tributyl-amine; In 1-methyl-pyrrolidin-2-one; at 200 ℃; for 2.5h; Inert atmosphere;

upstream raw materials:

(1s,3R,4s,5S)-4-aminoadamantan-1-ol

4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxamide

(1u202fs,3R,4s,5S,7s)-4-aminoadamantan-1-ol

4-aminoadamantan-1-ol

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