2-[(4S)-4,5-dihydro-4-phenyl-2-oxazolyl]- Pyridine

Base Information

Chemical Name:2-[(4S)-4,5-dihydro-4-phenyl-2-oxazolyl]- Pyridine
CAS No.:153880-57-0
Molecular Formula:C14H12N2O
Molecular Weight:224.262
Hs Code.:29349990
Mol file:153880-57-0.mol

Synonyms:2-[(4S)-4,5-dihydro-4-phenyl-2-oxazolyl]- Pyridine;(R)-2-(4-Phenyl-4,5-dihydro-oxazol-2-yl)-pyridine

Suppliers and Price of 2-[(4S)-4,5-dihydro-4-phenyl-2-oxazolyl]- Pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Frontier Specialty Chemicals
(R)-2-(4-Phenyl-4,5-dihydro-oxazol-2-yl)-pyridine 95%
250mg
$ 241.00

Crysdot
(R)-4-Phenyl-2-(pyridin-2-yl)-4,5-dihydrooxazole 97%
1g
$ 546.00

Ambeed
(S)-4-Phenyl-2-(pyridin-2-yl)-4,5-dihydrooxazole 98%99%ee
5g
$ 614.00

Ambeed
(S)-4-Phenyl-2-(pyridin-2-yl)-4,5-dihydrooxazole 98%99%ee
1g
$ 175.00

Ambeed
(S)-4-Phenyl-2-(pyridin-2-yl)-4,5-dihydrooxazole 98%99%ee
250mg
$ 60.00

Ambeed
(S)-4-Phenyl-2-(pyridin-2-yl)-4,5-dihydrooxazole 98%99%ee
100mg
$ 30.00

Total 8 raw suppliers

Chemical Property of 2-[(4S)-4,5-dihydro-4-phenyl-2-oxazolyl]- Pyridine

Chemical Property:

Boiling Point:397.9±35.0 °C(Predicted)
PKA:3.12±0.19(Predicted)
PSA：34.48000
Density:1.19±0.1 g/cm3(Predicted)
LogP:2.03530
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-(4-Phenyl-4,5-dihydro-oxazol-2-yl)-pyridine 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-[(4S)-4,5-dihydro-4-phenyl-2-oxazolyl]- Pyridine

There total 6 articles about 2-[(4S)-4,5-dihydro-4-phenyl-2-oxazolyl]- Pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 100-70-9,1232006-36-8
2-Cyanopyridine

: 20989-17-7
(2S)-2-phenylglycinol

: 153880-57-0
(S)-(-)-2-(4-phenyl-4,5-dihydro-1,3-oxazol-2-yl)pyridine

Guidance literature:: In neat (no solvent); at 150 ℃; for 1h; Microwave irradiation;
DOI:10.1016/j.tetasy.2014.08.010

Reference yield: 64.0%

: 20989-17-7
(2S)-2-phenylglycinol

: 19547-38-7
methyl pyridine-2-imidate

: 153880-57-0
(S)-(-)-2-(4-phenyl-4,5-dihydro-1,3-oxazol-2-yl)pyridine

Guidance literature:: In dichloromethane; for 60h; Reflux;
DOI:10.1021/acscatal.0c02569

Reference yield:

: 34375-80-9
4-phenyl-4-oxazoline-2-one

: 153880-57-0
(S)-(-)-2-(4-phenyl-4,5-dihydro-1,3-oxazol-2-yl)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: nickel diacetate; (+)-1,2-bis((2S,5S)-2,5-diphenylphospholanyl)ethane; hydrogen / 2,2,2-trifluoroethanol / 12 h / 50 °C / 760.05 Torr

2: 3-azapentane-1,5-diamine / 18 h / 140 °C

3: dichloromethane / 60 h / Reflux

With (+)-1,2-bis((2S,5S)-2,5-diphenylphospholanyl)ethane; hydrogen; nickel diacetate; 3-azapentane-1,5-diamine; In dichloromethane; 2,2,2-trifluoroethanol;
DOI:10.1021/acscatal.0c02569