1,4-Cyclohexadiene-1-ethanamine,N,alpha-dimethyl-,(alphaS)-(9CI)

Base Information

• Chemical Name: 1,4-Cyclohexadiene-1-ethanamine,N,alpha-dimethyl-,(alphaS)-(9CI)
• CAS No.: 74581-13-8
• Molecular Formula: C₁₁H₁₂N₂O₃
• Molecular Weight: 220.228
• Mol file: 74581-13-8.mol

Synonyms:1,4-Cyclohexadiene-1-ethanamine,N,alpha-dimethyl-,(alphaS)-(9CI)

Chemical Property of 1,4-Cyclohexadiene-1-ethanamine,N,alpha-dimethyl-,(alphaS)-(9CI)

Chemical Property:

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-Cyclohexadiene-1-ethanamine,N,alpha-dimethyl-,(alphaS)-(9CI)

There total 1 articles about 1,4-Cyclohexadiene-1-ethanamine,N,alpha-dimethyl-,(alphaS)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzylbismethoxycarbonylaminoacetamide (74581-12-7) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 4-methoxycarbonylamino-1,2,3,4-tetrahydro isoquinoline-3-one (74581-13-8) + (Benzylcarbamoyl-phenyl-methyl)-carbamic acid methyl ester (110599-50-3)

Guidance literature:

With methanesulfonic acid; for 24h; Yield given. Yields of byproduct given; ice-water cooling, RT;

DOI:10.1016/S0040-4020(01)89976-2

Reference yield:

trimethylsilyl iodide (16029-98-4) + 4-methoxycarbonylamino-1,2,3,4-tetrahydro isoquinoline-3-one (74581-13-8) → 4-amino-1,2,3,4-tetrahydroisoquinoline-3-one hydrobromide salt (1956306-14-1)

Guidance literature:

With sodium hydrogen sulfate; hydrogen bromide; In acetic acid; acetonitrile;

upstream raw materials:

N-benzylbismethoxycarbonylaminoacetamide

benzene

Downstream raw materials:

4-amino-1,2,3,4-tetrahydroisoquinoline-3-one hydrobromide salt