4-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy}benzenecarbaldehyde

Base Information

• Chemical Name: 4-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy}benzenecarbaldehyde
• CAS No.: 950994-19-1
• Molecular Formula: C13H7ClF3NO2
• Molecular Weight: 301.6483896
• Hs Code.: 2933399090
• Mol file: 950994-19-1.mol

Synonyms:4-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy}benzenecarbaldehyde

Chemical Property of 4-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy}benzenecarbaldehyde

Chemical Property:

• Boiling Point: 106℃/0.1mm
• PSA: 39.19000
• LogP: 4.35860

Purity/Quality:

98%min ^*data from raw suppliers

4-{[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy}benzenecarbaldehyde

There total 1 articles about 4-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy}benzenecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)benzaldehyde (950994-19-1)

Guidance literature:

Reference yield: 67.0%

4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)benzaldehyde (950994-19-1) + acrylonitrile (107-13-1,25014-41-9) → 2-((4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl)(hydroxy)methyl)acrylonitrile (950994-22-6)

Guidance literature:

With trimethylamine; In methanol; at 20 ℃; for 336h;

DOI:10.1016/j.jfluchem.2006.07.011

Reference yield: 48.0%

4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)benzaldehyde (950994-19-1) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 2-((4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl)(hydroxy)methyl)acrylate (950994-21-5)

Guidance literature:

With trimethylamine; In methanol; at 20 ℃; for 480h;

DOI:10.1016/j.jfluchem.2006.07.011

Downstream raw materials:

2-((4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl)(hydroxy)methyl)acrylonitrile

methyl 2-((4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl)(hydroxy)methyl)acrylate

Refernces

• 1、 -. "2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS". Page/Page column 60. . Retrieved 2009/07/17.