2-Propenoic acid, 3-[3-[(phenylaMino)sulfonyl]phenyl]-, ethyl ester, (2E)-

Base Information

Chemical Name:2-Propenoic acid, 3-[3-[(phenylaMino)sulfonyl]phenyl]-, ethyl ester, (2E)-
CAS No.:1137621-29-4
Molecular Formula:C17H17NO4S
Molecular Weight:331.392
Hs Code.:
Mol file:1137621-29-4.mol

Synonyms:2-Propenoic acid, 3-[3-[(phenylaMino)sulfonyl]phenyl]-, ethyl ester, (2E)-;(2E)-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenoic acid,ethyl ester

Suppliers and Price of 2-Propenoic acid, 3-[3-[(phenylaMino)sulfonyl]phenyl]-, ethyl ester, (2E)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 2-Propenoic acid, 3-[3-[(phenylaMino)sulfonyl]phenyl]-, ethyl ester, (2E)-

Chemical Property:

Boiling Point:507.3±52.0 °C(Predicted)
PKA:8.31±0.10(Predicted)
PSA：80.85000
Density:1.294±0.06 g/cm3(Predicted)
LogP:4.21750
Storage Temp.:Refrigerator
Solubility.:Chloroform-d; Methanol; DMSO; Ethyl Acetate

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Belinostat Ethyl Acetate is an intermediate in the synthesis of Belinostat Acid (B131485). Belinostat Acid is a metabolite of Belinostat (B131400), a novel histone deacetylase 3 selective inhibitor, which protects the β cells from cytokine-induced apoptosis.

Technology Process of 2-Propenoic acid, 3-[3-[(phenylaMino)sulfonyl]phenyl]-, ethyl ester, (2E)-

There total 3 articles about 2-Propenoic acid, 3-[3-[(phenylaMino)sulfonyl]phenyl]-, ethyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1159834-58-8
ethyl (E)-3-(3-(chlorosulfonyl)phenyl)prop-2-enoate

: 62-53-3
aniline

: 1137621-29-4
(E)-3-(3-phenylsulfamoyl-phenyl)-acrylic acid ethyl ester

Guidance literature:: With dmap; In dichloromethane; at 25 - 30 ℃;

Reference yield: 69.0%

: 166338-06-3
N-phenyl-3-bromo-benzenesulfonamide

: 140-88-5,9003-32-1
ethyl acrylate

: 1137621-29-4
(E)-3-(3-phenylsulfamoyl-phenyl)-acrylic acid ethyl ester

Guidance literature:: With triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; at 45 - 90 ℃;

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 1137621-29-4
(E)-3-(3-phenylsulfamoyl-phenyl)-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / water / 20 - 30 °C

2.1: ethanol; tin(II) chloride dihdyrate / 25 - 82 °C

3.1: acetic acid; hydrogenchloride; sodium azide / water / -5 - 30 °C

3.2: -5 - 0 °C

4.1: dmap / dichloromethane / 25 - 30 °C

With hydrogenchloride; dmap; sodium azide; tin(II) chloride dihdyrate; ethanol; potassium carbonate; acetic acid; In dichloromethane; water;