2-Amino-6-bromo-3-fluorotoluene

Base Information

• Chemical Name: 2-Amino-6-bromo-3-fluorotoluene
• CAS No.: 1227210-36-7
• Molecular Formula: C7H7BrFN
• Molecular Weight: 204.042
• Mol file: 1227210-36-7.mol

Synonyms:2-Amino-6-bromo-3-fluorotoluene

Chemical Property of 2-Amino-6-bromo-3-fluorotoluene

Chemical Property:

• PSA: 26.02000
• LogP: 3.06000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

95% ^*data from raw suppliers

2-Amino-6-bromo-3-fluorotoluene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Amino-6-bromo-3-fluorotoluene

There total 3 articles about 2-Amino-6-bromo-3-fluorotoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-bromo-4-fluoro-2-methyl-3-nitro-benzene (1227210-35-6) → 3-bromo-6-fluoro-2-methyl-aniline (1227210-36-7)

Guidance literature:

1-bromo-4-fluoro-2-methyl-3-nitro-benzene; With hydrogenchloride; tin(II) chloride dihdyrate; In methanol; water; at 40 ℃; for 2h; Inert atmosphere;

With potassium carbonate; In methanol; water; pH=12;

Reference yield:

1-fluoro-3-methyl-2-nitro-benzene (3013-27-2) → 3-bromo-6-fluoro-2-methyl-aniline (1227210-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; N-Bromosuccinimide / 2 h / 20 °C

2: iron; ammonium chloride / ethanol / 3 h / Reflux

With N-Bromosuccinimide; sulfuric acid; iron; ammonium chloride; In ethanol;

Reference yield:

4-Bromo-1-fluoro-2-nitrobenzene (364-73-8) → 3-bromo-6-fluoro-2-methyl-aniline (1227210-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / -35 °C / Inert atmosphere

2: hydrogenchloride; tin(II) chloride dihdyrate / water; methanol / 2 h / 40 °C

With hydrogenchloride; tin(II) chloride dihdyrate; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.bmcl.2015.11.076

upstream raw materials:

1-bromo-4-fluoro-2-methyl-3-nitro-benzene

1-fluoro-3-methyl-2-nitro-benzene

4-Bromo-1-fluoro-2-nitrobenzene

Downstream raw materials:

6-fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

tert-butyl N-tert-butoxycarbonyl-N-[6-fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate

tert-butyl N-tert-butoxycarbonyl-N-(6-fluoro-3-hydroxy-2-methyl-phenyl)carbamate

2-methyl-3-hydroxy-6-fluoroaniline