Chemical Property of 4-({[(4-Tert-Butylphenyl)sulfonyl]amino}methyl)-N-(Pyridin-3-Yl)benzamide
Chemical Property:
- PKA:11.28±0.50(Predicted)
- PSA：96.54000
- Density:1.247±0.06 g/cm3(Predicted)
- LogP:5.65460
- Storage Temp.:?20°C
- Solubility.:DMSO: soluble20mg/mL, clear
- XLogP3:3.8
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:7
- Exact Mass:423.16166284
- Heavy Atom Count:30
- Complexity:652
- Purity/Quality:
-
99%, *data from raw suppliers
STF 31 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
22
- Safety Statements:
46
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NCC2=CC=C(C=C2)C(=O)NC3=CN=CC=C3
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Description
Glucose transporter 1 (Glut1) is an inducible carrier of pentoses and hexoses, including glucose. STF-31 is an inhibitor of Glut1 (IC50 = ~1 μM) that blocks glucose uptake. It induces necrosis in cancer cells that lack the von Hippel-Lindau tumor suppressor gene, which overexpress Glut1. Although STF-31 binds Glut1, suggesting a direct effect, STF-31 also inhibits nicotinamide phosphoribosyltransferase, an enzyme that induces Glut1 expression. STF-31 is also toxic to human pluripotent stem cells (hPSCs) and can be used to selectively eliminate hPSCs from mixed cultures.
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Uses
STF 31 is used in biological studies as pyridylanilinothiazoles and pyridylphenylsulfonyl benzamides scaffolds use to prepare affinity chromatoraphy reagents for cancer targeting. STF 31 is an inhibitor of GLUT1 which blocks glucose uptake.
