Octahydro-2H-pyrano[3,2-c]pyridine

Base Information

• Chemical Name: Octahydro-2H-pyrano[3,2-c]pyridine
• CAS No.: 71671-81-3
• Molecular Formula: C8H15NO
• Molecular Weight: 141.213
• Mol file: 71671-81-3.mol

Synonyms:Octahydro-2H-pyrano[3,2-c]pyridine

Chemical Property of Octahydro-2H-pyrano[3,2-c]pyridine

Chemical Property:

• Boiling Point: 69.5-71 °C(Press: 2 Torr)
• PKA: 10.62±0.20(Predicted)
• PSA: 21.26000
• Density: 0.970±0.06 g/cm3(Predicted)
• LogP: 1.10370
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

Octahydro-2H-pyrano[3,2-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Octahydro-2H-pyrano[3,2-c]pyridine

There total 6 articles about Octahydro-2H-pyrano[3,2-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H23NO3 (1332455-45-4) → octahydro-2H-pyrano[3,2-c]pyridine (71671-81-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 18 - 25 ℃; for 6h;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → octahydro-2H-pyrano[3,2-c]pyridine (71671-81-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyrrolidine / ethanol / 16 h / Molecular sieve; Reflux

1.2: 4 h / Reflux

2.1: ethanol; sodium tetrahydroborate / 4 h / 18 - 25 °C

3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0.5 h / 0 °C

3.2: 4 h / 100 °C

4.1: trifluoroacetic acid / dichloromethane / 6 h / 18 - 25 °C

With pyrrolidine; sodium tetrahydroborate; ethanol; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane;

Reference yield:

tert-butyl 3-(3-methoxy-3-oxopropyl)-4-oxopiperidine-1-carboxylate (1332455-43-2) → octahydro-2H-pyrano[3,2-c]pyridine (71671-81-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethanol; sodium tetrahydroborate / 4 h / 18 - 25 °C

2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0.5 h / 0 °C

2.2: 4 h / 100 °C

3.1: trifluoroacetic acid / dichloromethane / 6 h / 18 - 25 °C

With sodium tetrahydroborate; ethanol; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; In dichloromethane;

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

tert-butyl 3-(3-methoxy-3-oxopropyl)-4-oxopiperidine-1-carboxylate

C₁₃H₂₅NO₄

C₁₃H₂₃NO₃

Refernces

• 1、 -. "TASK CHANNEL ANTAGONISTS". . . Retrieved 2011/09/30.