5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile

Base Information

Chemical Name:5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile
CAS No.:1338365-54-0
Molecular Formula:C22H25N3O2
Molecular Weight:363.459
Hs Code.:
Mol file:1338365-54-0.mol

Synonyms:5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile

Suppliers and Price of 5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile
250mg
$ 165.00

Total 6 raw suppliers

Chemical Property of 5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile

Chemical Property:

Boiling Point:567.4±50.0 °C(Predicted)
PKA:9.65±0.10(Predicted)
PSA：79.35000
Density:1.20±0.1 g/cm3(Predicted)
LogP:3.82288

Purity/Quality:

> 95% ^*data from raw suppliers

5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile, is used the preparation of various indoline derivatives and is an intermediate in the synthesis of (R)-Silodosin.

Technology Process of 5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile

There total 20 articles about 5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.1%

: 350797-56-7
1-(3-benzoyloxypropyl)-7-cyano-5-(2-nitropropyl)-2,3-dihydroindole

: 1338365-54-0,1201180-97-3
5-(2-aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-7-cyano-1H-indole

Guidance literature:: With hydrogenchloride; zinc; In ethanol; water; at 30 ℃; for 15h; Temperature; Concentration;

Reference yield: 91.3%

: C₃₀H₃₃N₃O₃

: 1338365-54-0,1201180-97-3
5-(2-aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-7-cyano-1H-indole

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 80 ℃; for 2.5h; under 12751.3 Torr; Pressure; Temperature; Green chemistry;

Reference yield:

: 350797-52-3
1-(3-benzoyloxypropyl)-5-formyl-2,3-dihydroindole

: 1338365-54-0,1201180-97-3
5-(2-aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-7-cyano-1H-indole

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate / 1 h / Reflux

2.1: ethanol; sodium tetrahydroborate / tetrahydrofuran / 1.5 h / 20 °C / cooling with ice

2.2: 1 h / pH 4

3.1: trichlorophosphate / 0.83 h / cooling with ice

3.2: 2.58 h / 50 °C

4.1: hydroxylamine hydrochloride; pyridine / tetrahydrofuran / 1 h / 50 °C

4.2: 3.5 h / 50 °C / Reflux

5.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 40 °C / 750.08 Torr

With pyridine; sodium tetrahydroborate; ethanol; hydroxylamine hydrochloride; hydrogen; trichlorophosphate; palladium 10% on activated carbon; ammonium acetate; In tetrahydrofuran; methanol;