Technology Process of 5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile
There total 20 articles about 5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride; zinc;
In
ethanol; water;
at 30 ℃;
for 15h;
Temperature;
Concentration;
- Guidance literature:
-
With
palladium on activated charcoal; hydrogen;
In
methanol;
at 80 ℃;
for 2.5h;
under 12751.3 Torr;
Pressure;
Temperature;
Green chemistry;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: ammonium acetate / 1 h / Reflux
2.1: ethanol; sodium tetrahydroborate / tetrahydrofuran / 1.5 h / 20 °C / cooling with ice
2.2: 1 h / pH 4
3.1: trichlorophosphate / 0.83 h / cooling with ice
3.2: 2.58 h / 50 °C
4.1: hydroxylamine hydrochloride; pyridine / tetrahydrofuran / 1 h / 50 °C
4.2: 3.5 h / 50 °C / Reflux
5.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 40 °C / 750.08 Torr
With
pyridine; sodium tetrahydroborate; ethanol; hydroxylamine hydrochloride; hydrogen; trichlorophosphate;
palladium 10% on activated carbon; ammonium acetate;
In
tetrahydrofuran; methanol;