9-[2,5-Anhydro-4-C-(hydroxymethyl)-alpha-L-lyxofuranosyl]-9H-purin-6-amine

Base Information

Chemical Name:9-[2,5-Anhydro-4-C-(hydroxymethyl)-alpha-L-lyxofuranosyl]-9H-purin-6-amine
CAS No.:206055-70-1
Molecular Formula:C11H13N5O4
Molecular Weight:279.255
Hs Code.:
Mol file:206055-70-1.mol

Synonyms:9-[2,5-Anhydro-4-C-(hydroxymethyl)-alpha-L-lyxofuranosyl]-9H-purin-6-amine

Suppliers and Price of 9-[2,5-Anhydro-4-C-(hydroxymethyl)-alpha-L-lyxofuranosyl]-9H-purin-6-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 11 raw suppliers

Chemical Property of 9-[2,5-Anhydro-4-C-(hydroxymethyl)-alpha-L-lyxofuranosyl]-9H-purin-6-amine

Chemical Property:

Melting Point:267 - 270 °C
PSA：128.54000
LogP:-0.99070

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of 9-[2,5-Anhydro-4-C-(hydroxymethyl)-alpha-L-lyxofuranosyl]-9H-purin-6-amine

There total 26 articles about 9-[2,5-Anhydro-4-C-(hydroxymethyl)-alpha-L-lyxofuranosyl]-9H-purin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 293751-34-5
((1S,3R,4R,7R)-3-(6-amino-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxa-bicyclo-[2.2.1]heptan-1-yl)methanol

: 206055-70-1
(1S,3R,4R,7S)-3-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-7-ol

Guidance literature:: With 10 wt% Pd(OH)2 on carbon; hydrogen; In ethanol; water; at 60 - 70 ℃; under 3040.2 Torr; Large scale;

Reference yield: 84.0%

: 206055-66-5
N-[9-((1S,3R,4R,7S)-7-Benzyloxy-1-benzyloxymethyl-2,5-dioxa-bicyclo[2.2.1]hept-3-yl)-9H-purin-6-yl]-benzamide

: 206055-70-1
(1S,3R,4R,7S)-3-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-7-ol

Guidance literature:: With boron trichloride; In hexane; dichloromethane; 1.) -78 deg C, 7 h, 2.) -78 deg C -> room temperature, 30 min;
DOI:10.1016/S0040-4020(98)00094-5

Reference yield:

: 63593-03-3
1,2-O-isopropylidene-3-O-benzyl-4-hydroxymethyl-α-D-ribofuranose

: 206055-70-1
(1S,3R,4R,7S)-3-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-7-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 98 percent / pyridine / 1 h / 20 °C

2.1: 97 percent / conc. H₂SO₄ / acetic acid / 24 h / 20 °C

3.1: N,O-bis(trimethylsilyl)acetamide / 1,2-dichloro-ethane / 1 h / Heating

3.2: 68 percent / trimethylsilyl triflate / 1,2-dichloro-ethane / 29 h / Heating

4.1: 78 percent / conc. NH₄OH / dioxane / 20 °C

5.1: 84 percent / dimethylformamide / 4 h / 100 °C

6.1: HCO₂NH₄ / Pd(OH)2/C / methanol; dioxane / Heating

With pyridine; ammonium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; sulfuric acid; ammonium formate; palladium dihydroxide; In 1,4-dioxane; methanol; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jo010732p