exo-(+)-1R,2R,4S-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane dihydrochloride

Base Information

Chemical Name:exo-(+)-1R,2R,4S-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane dihydrochloride
CAS No.:166374-43-2
Molecular Formula:C₁₁H₁₃ClN₂*ClH
Molecular Weight:245.152
Hs Code.:
Mol file:166374-43-2.mol

Synonyms:exo-(+)-1R,2R,4S-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane dihydrochloride;3-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane,dihydrochloride;

Suppliers and Price of exo-(+)-1R,2R,4S-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane dihydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(±)-EpibatidineDihydrochloride
10mg
$ 940.00

TRC
(±)-EpibatidineDihydrochloride
5mg
$ 500.00

TRC
(±)-EpibatidineDihydrochloride
1mg
$ 115.00

American Custom Chemicals Corporation
(+) EPIBATIDINE HYDROCHLORIDE 95.00%
5MG
$ 1577.96

Total 2 raw suppliers

Chemical Property of exo-(+)-1R,2R,4S-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane dihydrochloride

Chemical Property:

PSA：24.92000
LogP:4.27570
Solubility.:H2O: soluble10mg/mL

Purity/Quality:

97% ^*data from raw suppliers

(±)-EpibatidineDihydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T+
Statements: 27/28
Safety Statements: 28-36/37-45

MSDS Files:: SDS file from LookChem

Useful:

Uses (±)-Epibatidine Dihydrochloride is an alkaloid and an α4β2 selective nicotinic agonist (1). It has binding affinities for α4β2 and α3β4 nicotinic receptors (2).

Technology Process of exo-(+)-1R,2R,4S-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane dihydrochloride

There total 26 articles about exo-(+)-1R,2R,4S-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (1R,2R,4S)-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester

: 152885-09-1,162885-01-0,166374-43-2
(+)-epibatidine hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate;
DOI:10.1039/c39930001216

Reference yield: 100.0%

: (1R,2R,4S)-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester

: 152885-09-1,162885-01-0,166374-43-2
(-)-epibatidine hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate;
DOI:10.1039/c39930001216

Reference yield:

: 69045-79-0
2-choro-5-iodopyridine

: 152885-09-1,162885-01-0,166374-43-2
(+)-epibatidine hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) n-BuLi / 1.) Et₂O, THF, -70 deg C

2: 1.) KH / 1.) THF, from 0 deg C to RT, 2.) THF, 0 deg C

3: toluene / 2 h / 110 °C

4: H₂ / PtO₂ / ethyl acetate / 2068.6 Torr

5: t-BuOK / 2-methyl-propan-2-ol / 30 h / 100 °C

7: 100 percent / HCl / ethyl acetate

With hydrogenchloride; n-butyllithium; potassium tert-butylate; hydrogen; potassium hydride; platinum(IV) oxide; In ethyl acetate; toluene; tert-butyl alcohol;
DOI:10.1039/c39930001216