(8aS)-octahydro-8a-Methyl-Pyrrolo[1,2-a]pyrazine

Base Information

• Chemical Name: (8aS)-octahydro-8a-Methyl-Pyrrolo[1,2-a]pyrazine
• CAS No.: 1261569-85-0
• Molecular Formula: C₈H₁₆N₂
• Molecular Weight: 140.228
• Mol file: 1261569-85-0.mol

Synonyms:(8aS)-octahydro-8a-Methyl-Pyrrolo[1,2-a]pyrazine;(S)-Octahydro-8a-Methylpyrrolo[1,2-a]pyrazine;(8aS)-8a-methyl-octahydropyrrolo[1,2-a]piperazine;(S)-8a-Methyloctahydropyrrolo[1,2-a]pyrazine

Chemical Property of (8aS)-octahydro-8a-Methyl-Pyrrolo[1,2-a]pyrazine

Chemical Property:

• Boiling Point: 198.4±8.0 °C(Predicted)
• PKA: 10.02±0.40(Predicted)
• PSA: 15.27000
• Density: 1.01±0.1 g/cm3(Predicted)
• LogP: 0.71080

Purity/Quality:

99%, ^*data from raw suppliers

(8aS)-8a-methyl-octahydropyrrolo[1,2-a]piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (8aS)-octahydro-8a-Methyl-Pyrrolo[1,2-a]pyrazine

There total 4 articles about (8aS)-octahydro-8a-Methyl-Pyrrolo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(8aS)-8a-methylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione (847952-36-7,1638744-87-2) → (S)-8a-methyloctahydropyrrolo[1,2-a]pyrazine (1261569-85-0,1638744-57-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Reflux;

DOI:10.1016/j.bmcl.2010.10.061

Reference yield:

(S)-2-methylpyrrolidine-2-carboxylic acid (42856-71-3) → (S)-8a-methyloctahydropyrrolo[1,2-a]pyrazine (1261569-85-0,1638744-57-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: thionyl chloride / 3 h

2.1: triethylamine / dichloromethane / 0.17 h / 20 °C

2.2: 20 °C

3.1: palladium on activated charcoal; hydrogen / methanol / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 75 °C

With lithium aluminium tetrahydride; thionyl chloride; palladium on activated charcoal; hydrogen; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

methyl (S)-2-methylpyrrolidine-2-carboxylate monohydrochloride (220060-08-2,51098-46-5,1286768-32-8) → (S)-8a-methyloctahydropyrrolo[1,2-a]pyrazine (1261569-85-0,1638744-57-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.17 h / 20 °C

1.2: 20 °C

2.1: palladium on activated charcoal; hydrogen / methanol / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 75 °C

With lithium aluminium tetrahydride; palladium on activated charcoal; hydrogen; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

upstream raw materials:

(8aS)-8a-methylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

(S)-2-methylpyrrolidine-2-carboxylic acid

methyl (S)-2-methylpyrrolidine-2-carboxylate monohydrochloride

(S)-methyl 1-(2-(((benzyloxy)carbonyl)amino)acetyl)-2-methylpyrrolidine-2-carboxylate

Downstream raw materials:

C₂₅H₃₅N₃O₂

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