Methyl 2-[5-[2-(2,4-Dichlorophenoxy)phenyl]-2H-tetrazol-2-yl]acetate

Base Information

• Chemical Name: Methyl 2-[5-[2-(2,4-Dichlorophenoxy)phenyl]-2H-tetrazol-2-yl]acetate
• CAS No.: 1314406-38-6
• Molecular Formula: C16H12Cl2N4O3
• Molecular Weight: 379.19748
• Mol file: 1314406-38-6.mol

Synonyms:Methyl 2-[5-[2-(2,4-Dichlorophenoxy)phenyl]-2H-tetrazol-2-yl]acetate;5-[2-(2,4-dichlorophenoxy)phenyl]-2H-Tetrazole-2-acetic acid methyl ester

Chemical Property of Methyl 2-[5-[2-(2,4-Dichlorophenoxy)phenyl]-2H-tetrazol-2-yl]acetate

Chemical Property:

• Boiling Point: 502.2±60.0 °C(Predicted)
• PKA: -0.36±0.12(Predicted)
• PSA: 79.13000
• Density: 1.47±0.1 g/cm3(Predicted)
• LogP: 3.61220

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-[5-[2-(2,4-Dichlorophenoxy)phenyl]-2H-tetrazol-2-yl]acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-[5-[2-(2,4-Dichlorophenoxy)phenyl]-2H-tetrazol-2-yl]acetate

There total 2 articles about Methyl 2-[5-[2-(2,4-Dichlorophenoxy)phenyl]-2H-tetrazol-2-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

5-(2-(2,4-dichlorophenoxy)phenyl)-2H-tetrazole (671186-08-6) + bromoacetic acid methyl ester (96-32-2) → methyl 2-(5-(2-(2,4-dichlorophenoxy)phenyl)-2H-tetrazol-2-yl)acetate (1314406-38-6) + methyl 2-(5-(2-(2,4-dichlorophenoxy)phenyl)-1H-tetrazol-1-yl)acetate (1479164-75-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; Reflux;

DOI:10.1002/cmdc.201400058

Reference yield:

2-(2,4-dichlorophenoxy)benzonitrile (175136-80-8) → methyl 2-(5-(2-(2,4-dichlorophenoxy)phenyl)-2H-tetrazol-2-yl)acetate (1314406-38-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide; triethylamine hydrochloride / N,N-dimethyl-formamide / Reflux

2: sodium hydride / tetrahydrofuran / Reflux

With sodium azide; triethylamine hydrochloride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201400058

Reference yield: 92.0%

methyl 2-(5-(2-(2,4-dichlorophenoxy)phenyl)-2H-tetrazol-2-yl)acetate (1314406-38-6) → 2-(5-(2-(2,4-dichlorophenoxy)phenyl)-2H-tetrazol-2-yl)acetohydrazide (685120-57-4)

Guidance literature:

With hydrazine hydrate; In tetrahydrofuran; for 12h; Reflux;

DOI:10.1002/cmdc.201400058

upstream raw materials:

2-(2,4-dichlorophenoxy)benzonitrile

5-(2-(2,4-dichlorophenoxy)phenyl)-2H-tetrazole

bromoacetic acid methyl ester

Downstream raw materials:

2-(2-(5-(2-(2,4-dichlorophenoxy)phenyl)-2H-tetrazol-2-yl)acetyl)-N-(3-methoxyphenyl)hydrazinecarbothioamide

2-(2-(5-(2-(2,4-dichlorophenoxy)phenyl)-2H-tetrazol-2-yl)acetyl)-N-(3-nitrophenyl)hydrazinecarbothioamide

N-(4-chlorophenyl)-2-(2-(5-(2-(2,4-dichlorophenoxy)phenyl)-2H-tetrazol-2-yl)acetyl)hydrazinecarbothioamide

2-(2-(5-(2-(2,4-dichlorophenoxy)phenyl)-2H-tetrazol-2-yl)acetyl)-N-(4-methoxyphenyl)hydrazinecarbothioamide

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