AKOS B014790

Base Information

• Chemical Name: AKOS B014790
• CAS No.: 355001-08-0
• Molecular Formula: C10H15N3OS
• Molecular Weight: 225.31
• Hs Code.: 2934999090
• Mol file: 355001-08-0.mol

Synonyms:AKOS B014790;ART-CHEM-BB B014790;2-Amino-6-ethyl-4,5,6,7-tetrahydro-thieno[2,3-c]-pyridine-3-carboxylic acid amide;2-amino-6-ethyl-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxamide;MLS000570607;Oprea1_294773;Oprea1_309501;SDCCGMLS-0064989.P001

Chemical Property of AKOS B014790

Chemical Property:

• PSA: 100.59000
• LogP: 2.02660

Purity/Quality:

98%min ^*data from raw suppliers

2-amino-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS B014790

There total 1 articles about AKOS B014790 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

N-ethyl-4-piperidone (3612-18-8) + cyanoacetic acid amide (107-91-5) → 2-amino-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide (355001-08-0)

Guidance literature:

With morpholine; sulfur; In ethanol; for 5h; Inert atmosphere; Reflux;

DOI:10.1021/acs.jmedchem.7b00932

Reference yield:

2-amino-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide (355001-08-0) + 2-naphthylisocyanate (2243-54-1) → 6-ethyl-2-{[(naphthalen-2-yl)carbamoyl]amino}-4H,5H,6H,7H-thieno[2,3-c]pyridine-3-carboxamide hydrochloride

Guidance literature:

2-amino-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide; 2-naphthylisocyanate; With triethylamine; In tetrahydrofuran; dichloromethane; at 25 ℃; Inert atmosphere;

With hydrogenchloride; In diethyl ether; dichloromethane; at 25 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.7b00932

Reference yield:

2-amino-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide (355001-08-0) → 3-carbamoyl-2-[3-(4-chlorophenyl)ureido]-6-ethyl-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-6-ium iodide

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran; dichloromethane / 25 °C / Inert atmosphere

2: hydrogenchloride / dichloromethane; diethyl ether / 25 °C / Inert atmosphere

3: N,N-dimethyl-formamide / 18 h / 25 °C / Inert atmosphere

With hydrogenchloride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.7b00932

upstream raw materials:

N-ethyl-4-piperidone

cyanoacetic acid amide

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