2-Thiophen-2-yl-cyclopropanecarboxylic acid

Base Information

• Chemical Name: 2-Thiophen-2-yl-cyclopropanecarboxylic acid
• CAS No.: 90111-23-2
• Molecular Formula: C₈H₈O₂S
• Molecular Weight: 168.216
• Hs Code.: 2934999090
• Mol file: 90111-23-2.mol

Synonyms:2-Thiophen-2-yl-cyclopropanecarboxylic acid

Chemical Property of 2-Thiophen-2-yl-cyclopropanecarboxylic acid

Chemical Property:

• Melting Point: 124-125 °C
• Boiling Point: 333.9±35.0 °C(Predicted)
• PKA: 4.51±0.11(Predicted)
• PSA: 65.54000
• Density: 1.411±0.06 g/cm3(Predicted)
• LogP: 1.93620
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

≥95% ^*data from raw suppliers

2-(thiophen-2-yl)cyclopropane-1-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Thiophen-2-yl-cyclopropanecarboxylic acid

There total 9 articles about 2-Thiophen-2-yl-cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trimethylsulfoxonium iodide (1774-47-6) + ethyl (E)-3-(thiophen-2-yl)acrylate (13979-15-2,70326-81-7) → trans-2-(2-thienyl)cyclopropanecarboxylic acid (3972-50-7,4085-30-7,90111-23-2)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol4003338

Reference yield:

(1S,2S)-2-Thiophen-2-yl-cyclopropanecarboxylic acid methyl ester → trans-2-(2-thienyl)cyclopropanecarboxylic acid (3972-50-7,4085-30-7,90111-23-2)

Guidance literature:

With sodium hydroxide; In methanol; for 2h; Yield given; Ambient temperature;

DOI:10.1021/jm9507136

Reference yield:

→ cis-2--cyclopropan-carbonsaeure (3972-50-7,4085-30-7,90111-23-2) + trans-2-(2-thienyl)cyclopropanecarboxylic acid (3972-50-7,4085-30-7,90111-23-2)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01178a010

upstream raw materials:

methyl (E)-3-(2-thienyl)propenoate

thiophene-2-carbaldehyde

trimethylsulfoxonium iodide

ethyl (E)-3-(thiophen-2-yl)acrylate

Refernces

• 1、 Vallgarda,Appelberg,Arvidsson,Hjorth,Svensson,Hacksell. "trans-2-Aryl-N,N-dipropylcyclopropylamines: Synthesis and interactions with 5-HT(1A) receptors". . p. 1485 - 1493. Retrieved 2007/10/03.