Hexahydro-oxazolo[3,4-a]pyrazin-3-one HCl

Base Information

• Chemical Name: Hexahydro-oxazolo[3,4-a]pyrazin-3-one HCl
• CAS No.: 1020349-31-8
• Molecular Formula: C6H11ClN2O2
• Molecular Weight: 178.619
• Hs Code.: 2934999090
• Mol file: 1020349-31-8.mol

Synonyms:Hexahydro-oxazolo[3,4-a]pyrazin-3-one HCl;Tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride;hexahydro-Oxazolo[3,4-a]pyrazin-3-one hydrochloride;3H-Oxazolo[3,4-a]pyrazin-3-one, hexahydro-, hydrochloride

Chemical Property of Hexahydro-oxazolo[3,4-a]pyrazin-3-one HCl

Chemical Property:

• PSA: 41.57000
• LogP: 0.47910
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

1,5,6,7,8,8a-Hexahydro-[1,3]oxazolo[3,4-a]pyrazin-3-oneHydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Hexahydro-oxazolo[3,4-a]pyrazin-3-one HCl

There total 3 articles about Hexahydro-oxazolo[3,4-a]pyrazin-3-one HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tert-butyl 3-oxotetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxylate (935544-47-1,1235469-36-9) → tetrahydrooxazolyl-1H-[3,4-a]pyrazin-3(5H)-one hydrochloride (1020349-31-8,1212327-95-1,958635-15-9)

Guidance literature:

With hydrogenchloride; In dichloromethane; ethyl acetate; at 20 ℃; for 0.833333h; Inert atmosphere;

Reference yield:

tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate (301673-16-5) → tetrahydrooxazolyl-1H-[3,4-a]pyrazin-3(5H)-one hydrochloride (1020349-31-8,1212327-95-1,958635-15-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; methanol / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

1.2: 6 h / 65 °C

2.1: hydrogenchloride / dichloromethane; ethyl acetate / 0.83 h / 20 °C / Inert atmosphere

With hydrogenchloride; methanol; triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate;

Reference yield:

tert-butyl methyl piperazine-1,3-dicarboxylate (129799-08-2) → tetrahydrooxazolyl-1H-[3,4-a]pyrazin-3(5H)-one hydrochloride (1020349-31-8,1212327-95-1,958635-15-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethanol; sodium tetrahydroborate; nickel dichloride / 4 h / 0 °C / Inert atmosphere

2.1: triethylamine; methanol / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

2.2: 6 h / 65 °C

3.1: hydrogenchloride / dichloromethane; ethyl acetate / 0.83 h / 20 °C / Inert atmosphere

With hydrogenchloride; methanol; sodium tetrahydroborate; ethanol; triethylamine; nickel dichloride; In tetrahydrofuran; dichloromethane; ethyl acetate;

upstream raw materials:

tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate

tert-butyl 3-oxotetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxylate

tert-butyl methyl piperazine-1,3-dicarboxylate

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