METHYL 2-FORMYLTHIAZOLE-5-CARBOXYLATE

Base Information

• Chemical Name: METHYL 2-FORMYLTHIAZOLE-5-CARBOXYLATE
• CAS No.: 1408075-35-3
• Molecular Formula: C₆H₅NO₃S
• Molecular Weight: 171.177
• Mol file: 1408075-35-3.mol

Synonyms:METHYL 2-FORMYLTHIAZOLE-5-CARBOXYLATE;methyl 2-formyl-1,3-thiazole-5-carboxylate

Chemical Property of METHYL 2-FORMYLTHIAZOLE-5-CARBOXYLATE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-Formylthiazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of METHYL 2-FORMYLTHIAZOLE-5-CARBOXYLATE

There total 2 articles about METHYL 2-FORMYLTHIAZOLE-5-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-vinylthiazole-5-carboxylate → methyl 2-formylthiazole-5-carboxylate (1408075-35-3)

Guidance literature:

With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; In 1,4-dioxane; water; at 20 ℃; Inert atmosphere;

Reference yield:

methyl 2-bromo-1,3-thiazole-5-carboxylate (54045-74-8) → methyl 2-formylthiazole-5-carboxylate (1408075-35-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,6-di-tert-butyl-4-methyl-phenol; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

2: sodium periodate; osmium(VIII) oxide; 2,6-dimethylpyridine / water; 1,4-dioxane / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butyl-4-methyl-phenol; In 1,4-dioxane; water;

Reference yield:

methyl 2-formylthiazole-5-carboxylate (1408075-35-3) → N-{3-[2-(4-chloro-3-fluorophenoxy)acetamido]bicyclo[1.1.1]pentan-1-yl}-2-(difluoromethyl)-1,3-thiazole-5-carboxamide

Guidance literature:

Multi-step reaction with 2 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / -5 - 20 °C

2.1: sodium hydroxide / ethanol / 0.05 h / 20 °C

2.2: 0.5 h / 20 °C

With diethylamino-sulfur trifluoride; sodium hydroxide; In ethanol; dichloromethane;

upstream raw materials:

methyl 2-bromo-1,3-thiazole-5-carboxylate

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