4-Methyl-3-Mercapto-5-(N-Methylpyrrol-2-yl)-1,2,4-(4H)-triazole

Base Information

Chemical Name:4-Methyl-3-Mercapto-5-(N-Methylpyrrol-2-yl)-1,2,4-(4H)-triazole
CAS No.:741690-24-4
Molecular Formula:C₈H₁₀N₄S
Molecular Weight:194.26
Hs Code.:
Mol file:741690-24-4.mol

Synonyms:4-Methyl-3-Mercapto-5-(N-Methylpyrrol-2-yl)-1,2,4-(4H)-triazole;English name 4-methyl-5-(1-methyl-1H-pyrrol-2-yl)-4H-1,2,4-triazole-3-thiol

Suppliers and Price of 4-Methyl-3-Mercapto-5-(N-Methylpyrrol-2-yl)-1,2,4-(4H)-triazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 5 raw suppliers

Chemical Property of 4-Methyl-3-Mercapto-5-(N-Methylpyrrol-2-yl)-1,2,4-(4H)-triazole

Chemical Property:

PSA：74.44000
LogP:1.10930

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Methyl-3-Mercapto-5-(N-Methylpyrrol-2-yl)-1,2,4-(4H)-triazole

There total 2 articles about 4-Methyl-3-Mercapto-5-(N-Methylpyrrol-2-yl)-1,2,4-(4H)-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 741690-24-4
4-methyl-5-(1-methyl-1H-pyrrol-2-yl)-4H-1,2,4-triazole-3-thiol

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide; at 20 ℃; Cooling with ice; Inert atmosphere;

Reference yield:

: 6973-60-0
1-Methyl-2-pyrrolecarboxylic acid

: 6610-29-3
4-methylthiosemicarbazide

: 741690-24-4
4-methyl-5-(1-methyl-1H-pyrrol-2-yl)-4H-1,2,4-triazole-3-thiol

Guidance literature:: 1-Methyl-2-pyrrolecarboxylic acid; 4-methylthiosemicarbazide; With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide; at 20 ℃; for 12h;

With sodium hydroxide; for 0.666667h; Reflux;
DOI:10.1016/j.bmcl.2015.12.081

Reference yield:

: 741690-24-4
4-methyl-5-(1-methyl-1H-pyrrol-2-yl)-4H-1,2,4-triazole-3-thiol

: 4-(3-{[4-methyl-5-(1-methyl-1H-pyrrol-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}propyl)-2-[4-(trifluoromethyl)phenyl]morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol; acetone / 12 h / 20 °C

2: sodium carbonate; sodium iodide / N,N-dimethyl-formamide / 12 h / 60 °C

With sodium carbonate; potassium carbonate; sodium iodide; In methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2015.12.081