2-{[3-(trifluoromethyl)phenyl]methylene}-1H-indene-1,3(2H)-dione

Base Information

• Chemical Name: 2-{[3-(trifluoromethyl)phenyl]methylene}-1H-indene-1,3(2H)-dione
• CAS No.: 136758-25-3
• Molecular Formula: C17H9F3O2
• Molecular Weight: 302.252
• Mol file: 136758-25-3.mol

Synonyms:2-{[3-(trifluoromethyl)phenyl]methylene}-1H-indene-1,3(2H)-dione

Chemical Property of 2-{[3-(trifluoromethyl)phenyl]methylene}-1H-indene-1,3(2H)-dione

Chemical Property:

• Melting Point: 150 - 154 °C
• PSA: 34.14000
• LogP: 4.16800

Purity/Quality:

2-{[3-(Trifluoromethyl)phenyl]methylene}-1H-indene-1,3(2H)-dione ^*data from reagent suppliers

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Technology Process of 2-{[3-(trifluoromethyl)phenyl]methylene}-1H-indene-1,3(2H)-dione

There total 1 articles about 2-{[3-(trifluoromethyl)phenyl]methylene}-1H-indene-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1H-indene-1,3(2H)-dione (606-23-5) + 3-Trifluoromethylbenzaldehyde (454-89-7) → 2-(3-(trifluoromethyl)benzylidene)-1H-indene-1,3(2H)-dione (136758-25-3)

Guidance literature:

With piperidine; In ethanol; for 1h; Ambient temperature;

Reference yield: 71.0%

tert-butyl 3-acetoxy-2-methylenebutanoate (927408-60-4) + 2-(3-(trifluoromethyl)benzylidene)-1H-indene-1,3(2H)-dione (136758-25-3) → C43H32F6O6

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In N,N-dimethyl-formamide; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1039/c4ob01927j

Reference yield: 71.0%

2-(3-(trifluoromethyl)benzylidene)-1H-indene-1,3(2H)-dione (136758-25-3) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → (E)-11-(3-(trifluoromethyl)benzylidene)-5H-dibenzo[a,d][7]annulene-5,10(11H)-dione

Guidance literature:

With potassium fluoride; 18-crown-6 ether; In acetonitrile; at 25 ℃; Inert atmosphere;

DOI:10.1039/c9ob01900f

upstream raw materials:

1H-indene-1,3(2H)-dione

3-Trifluoromethylbenzaldehyde

Downstream raw materials:

2-Morpholin-4-yl-5-oxo-4-(3-trifluoromethyl-phenyl)-4,5-dihydro-indeno[1,2-b]pyran-3-carbonitrile

5-Oxo-2-piperidin-1-yl-4-(3-trifluoromethyl-phenyl)-4,5-dihydro-indeno[1,2-b]pyran-3-carboxylic acid methyl ester

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