5α-Pregnane-3,7,20-trione

Base Information

• Chemical Name: 5α-Pregnane-3,7,20-trione
• CAS No.: 26991-60-6
• Molecular Formula: C21H30O3
• Molecular Weight: 330.46
• Mol file: 26991-60-6.mol

Synonyms:5α-Pregnane-3,7,20-trione

Chemical Property of 5α-Pregnane-3,7,20-trione

Chemical Property:

• PSA: 51.21000
• LogP: 3.98240

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5α-Pregnane-3,7,20-trione

There total 8 articles about 5α-Pregnane-3,7,20-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5α-pregnane-3β,7ξ,20βF-triol (57071-94-0) → 5α-pregnane-3,7,20-trione (26991-60-6)

Guidance literature:

With chromium(VI) oxide;

DOI:10.1021/jo50010a024

Reference yield:

3β,20βF-diacetoxy-5α-pregnan-7-one (1805-20-5,1805-21-6,57071-98-4) → 5α-pregnane-3,7,20-trione (26991-60-6)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄; diethyl ether

2: CrO₃

With chromium(VI) oxide; lithium aluminium tetrahydride; diethyl ether;

DOI:10.1021/jo50010a024

Reference yield:

pregn-5-en-3β,20β-diyl diacetate (1913-46-8) → 5α-pregnane-3,7,20-trione (26991-60-6)

Guidance literature:

Multi-step reaction with 4 steps

1: CrO₃; acetic acid

2: palladium/charcoal / Hydrogenation

3: LiAlH₄; diethyl ether

4: CrO₃

With chromium(VI) oxide; palladium on activated charcoal; lithium aluminium tetrahydride; diethyl ether; acetic acid;

DOI:10.1021/jo50010a024

upstream raw materials:

5α-pregnane-3β,7ξ,20β_F-triol

3β-hydroxy-5α-pregnane-7,20-dione

7-ketopregnenolone acetate

Pregnenolone acetate