(1R,2S,5R*)-2-BENZYLOXYCARBONYLAMINO-5-HYDROXY-CYCLOHEXANECARBOXYLIC ACID

Base Information

Chemical Name:(1R*,2S*,5R*)-2-BENZYLOXYCARBONYLAMINO-5-HYDROXY-CYCLOHEXANECARBOXYLIC ACID
CAS No.:1212264-04-4
Molecular Formula:C15H19NO5
Molecular Weight:293.31506
Hs Code.:2924297099
Mol file:1212264-04-4.mol

Synonyms:(1R*,2S*,5R*)-2-BENZYLOXYCARBONYLAMINO-5-HYDROXY-CYCLOHEXANECARBOXYLIC ACID

Suppliers and Price of (1R*,2S*,5R*)-2-BENZYLOXYCARBONYLAMINO-5-HYDROXY-CYCLOHEXANECARBOXYLIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of (1R*,2S*,5R*)-2-BENZYLOXYCARBONYLAMINO-5-HYDROXY-CYCLOHEXANECARBOXYLIC ACID

Chemical Property:

PSA：99.35000
LogP:1.73140

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (1R*,2S*,5R*)-2-BENZYLOXYCARBONYLAMINO-5-HYDROXY-CYCLOHEXANECARBOXYLIC ACID

There total 9 articles about (1R*,2S*,5R*)-2-BENZYLOXYCARBONYLAMINO-5-HYDROXY-CYCLOHEXANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: ethyl (1RS,2RS,5SR)-2-(benzyloxycarbonylamino)-5-hydroxycyclohexanecarboxylate

: 1212264-04-4
(1RS,2RS,5SR)-2-(benzyloxycarbonylamino)-5-hydroxycyclohexanecarboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; water; at 20 ℃; for 3h;
DOI:10.1016/j.tetlet.2006.02.133

Reference yield: 87.0%

: 886232-02-6
ethyl (1R,2R,5S)-2-(benzyloxycarbonylamino)-5-hydroxycyclohexanecarboxylate

: 886232-03-7,1212264-04-4
(1R,2R,5S)-2-(benzyloxycarbonylamino)-5-hydroxycyclohexanecarboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; water; at 20 ℃; for 3h;
DOI:10.1016/j.tetlet.2006.02.133

Reference yield:

: 189125-31-3
(1R,2R)-trans-2-aminocyclohex-4-enecarboxylic acid

: 886232-03-7,1212264-04-4
(1R,2R,5S)-2-(benzyloxycarbonylamino)-5-hydroxycyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / SOCl₂ / 4 h / 70 °C

2: 91 percent / Et₃N / tetrahydrofuran / 16 h / 20 °C

3: 56 percent / MCPBA / CH₂Cl₂ / 6 h / 20 °C

4: 66 percent / NaBH₄ / ethanol / 2 h / 20 °C

5: 87 percent / NaOH / methanol; H₂O / 3 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; thionyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1016/j.tetlet.2006.02.133