(1S,2R,3S,4R)-4-aMino-2,3-dihydroxycyclopentanecarboxylic acid hydrochloride

Base Information

Chemical Name:(1S,2R,3S,4R)-4-aMino-2,3-dihydroxycyclopentanecarboxylic acid hydrochloride
CAS No.:872174-26-0
Molecular Formula:C₆H₁₁NO₄*ClH
Molecular Weight:197.619
Hs Code.:
Mol file:872174-26-0.mol

Synonyms:(1S,2R,3S,4R)-4-aMino-2,3-dihydroxycyclopentanecarboxylic acid hydrochloride;(1S,2R,3S,4R)-4-amino-2,3-dihydroxycyclopentane-1-carboxylicacidhydrochloride

Suppliers and Price of (1S,2R,3S,4R)-4-aMino-2,3-dihydroxycyclopentanecarboxylic acid hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of (1S,2R,3S,4R)-4-aMino-2,3-dihydroxycyclopentanecarboxylic acid hydrochloride

Chemical Property:

Purity/Quality:: 97-99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2R,3S,4R)-4-aMino-2,3-dihydroxycyclopentanecarboxylic acid hydrochloride

There total 20 articles about (1S,2R,3S,4R)-4-aMino-2,3-dihydroxycyclopentanecarboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141293-15-4
(1'S,2R,4''R)-2-[(2,2-dimethyl-[1,3]dioxolan-4-yl)hydroxymethyl]-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylic acid tert-butyl ester

: 872174-26-0
(1S,2S,3S,4R)-4-Amino-2,3-dihydroxy-cyclopentanecarboxylic acid; hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: 98 percent / H₂; NaOAc / Pd/C / ethyl acetate / 24 h / 20 °C

2.1: 95 percent / 2,6-lutidine / CH₂Cl₂ / 3 h / 20 °C

3.1: 93 percent / ammonium cerium(IV) nitrate / acetonitrile / 4 h / 80 °C

4.1: NaH / tetrahydrofuran / 0.17 h / 20 °C

4.2: 91 percent / tetrahydrofuran / 1.5 h / Heating

5.1: 98 percent / H₂IO₆ / ethyl acetate / 1 h / 20 °C

6.1: 78 percent / diisopropylethyl amine / CH₂Cl₂ / 2 h / 20 °C

7.1: 98 percent / NH₃; Na / tetrahydrofuran / 0.5 h / -78 °C

8.1: aq. HCl / 5 h / 80 °C

With 2,6-dimethylpyridine; hydrogenchloride; ammonium cerium(IV) nitrate; ammonia; hydrogen; sodium acetate; sodium; sodium hydride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jm050698x

Reference yield:

: 141293-15-4
(1'S,2R,4''R)-2-[(2,2-dimethyl-[1,3]dioxolan-4-yl)hydroxymethyl]-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylic acid tert-butyl ester

: 872174-26-0
(1S,2R,3S,4R)-4-Amino-2,3-dihydroxy-cyclopentanecarboxylic acid; hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: 98 percent / H₂; NaOAc / Pd/C / ethyl acetate / 24 h / 20 °C

2.1: 95 percent / 2,6-lutidine / CH₂Cl₂ / 3 h / 20 °C

3.1: 93 percent / ammonium cerium(IV) nitrate / acetonitrile / 4 h / 80 °C

4.1: NaH / tetrahydrofuran / 0.17 h / 20 °C

4.2: 91 percent / tetrahydrofuran / 1.5 h / Heating

5.1: 98 percent / H₂IO₆ / ethyl acetate / 1 h / 20 °C

6.1: 20 percent / diisopropylethyl amine / CH₂Cl₂ / 2 h / 20 °C

7.1: 97 percent / NH₃; Na / tetrahydrofuran / -78 °C

8.1: aq. HCl / 80 °C

With 2,6-dimethylpyridine; hydrogenchloride; ammonium cerium(IV) nitrate; ammonia; hydrogen; sodium acetate; sodium; sodium hydride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jm050698x