methyl 2-methyl-2-((piperazin-1-yl)methyl)propanoate

Base Information

• Chemical Name: methyl 2-methyl-2-((piperazin-1-yl)methyl)propanoate
• CAS No.: 224309-88-0
• Molecular Formula: C10H20N2O2
• Molecular Weight: 200.278
• Mol file: 224309-88-0.mol

Synonyms:methyl 2-methyl-2-((piperazin-1-yl)methyl)propanoate

Chemical Property of methyl 2-methyl-2-((piperazin-1-yl)methyl)propanoate

Chemical Property:

• PSA: 41.57000
• LogP: 0.35750

Purity/Quality:

99% ^*data from raw suppliers

a,a-dimethyl-1-Piperazinepropanoicacidmethylester 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-methyl-2-((piperazin-1-yl)methyl)propanoate

There total 3 articles about methyl 2-methyl-2-((piperazin-1-yl)methyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(3-methoxy-2,2-dimethyl-3-oxopropyl)piperazine-1-carboxylate (1342837-52-8) → methyl 2,2-dimethyl-3-(piperazin-1-yl)propanoate (224309-88-0)

Guidance literature:

With NaOH; trifluoroacetic acid; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield:

methyl 2,2-dimethyl-3-(piperazin-1-yl)propanoate hydrochloride (1392837-30-7) → methyl 2,2-dimethyl-3-(piperazin-1-yl)propanoate (224309-88-0)

Guidance literature:

With ammonia; In methanol;

Reference yield:

methyl 2,2-dimethyl-3-oxopropanoate (13865-20-8) → methyl 2,2-dimethyl-3-(piperazin-1-yl)propanoate (224309-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; NaBH(OAc)3 / water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

2: trifluoroacetic acid; NaOH / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

With NaOH; NaBH(OAc)3; sodium hydrogencarbonate; trifluoroacetic acid; In water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

upstream raw materials:

methyl 2,2-dimethyl-3-oxopropanoate

tert-butyl 4-(3-methoxy-2,2-dimethyl-3-oxopropyl)piperazine-1-carboxylate

methyl 2,2-dimethyl-3-(piperazin-1-yl)propanoate hydrochloride

Refernces

• 1、 -. "SUBSTITUTED [(5H-PYRROLO[2,1-c][1,4]BENZODIAZEPIN-11-YL)PIPERAZIN-1-YL]-2,2-DIMETHYLPROPANOIC ACID COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS". Page/Page column 17. . Retrieved 2012/08/27.