18-Methylprogesterone

Base Information

• Chemical Name: 18-Methylprogesterone
• CAS No.: 5895-84-1
• Molecular Formula: C₂₂H₃₂O₂
• Molecular Weight: 328.495
• Mol file: 5895-84-1.mol

Synonyms:13-Ethyl-18-norpregn-4-ene-3,20-dione;18-Methylprogesterone

Chemical Property of 18-Methylprogesterone

Chemical Property:

• PSA: 34.14000
• LogP: 5.11360

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 18-Methylprogesterone

There total 9 articles about 18-Methylprogesterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H36O3 (16318-36-8) → 13-ethyl-18-norpregn-4-ene-3,20-dione (5895-84-1)

Guidance literature:

With toluene-4-sulfonic acid; In acetone; for 1h; Yield given; Heating;

DOI:10.1016/0039-128X(85)90078-9

Reference yield:

C24H38O3 (101554-62-5) → 13-ethyl-18-norpregn-4-ene-3,20-dione (5895-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1: CrO₃ / pyridine

2: p-toluenesulphonic acid / acetone / 1 h / Heating

With chromium(VI) oxide; toluene-4-sulfonic acid; In pyridine; acetone;

DOI:10.1016/0039-128X(85)90078-9

Reference yield:

C24H36O4 (23971-03-1) → 13-ethyl-18-norpregn-4-ene-3,20-dione (5895-84-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) N₂H₄*H₂O, conc. HCl, 2) KOH / 1) EtOH, diethylene glycol, reflux, 1.5 h, 2) EtOH, diethylene glycol, 200 deg C, 3.5 h

2: CrO₃ / pyridine

3: p-toluenesulphonic acid / acetone / 1 h / Heating

With chromium(VI) oxide; hydrogenchloride; potassium hydroxide; toluene-4-sulfonic acid; hydrazine hydrate; In pyridine; acetone;

DOI:10.1016/0039-128X(85)90078-9

upstream raw materials:

C₂₄H₃₆O₃

C₂₄H₃₈O₃

C₂₄H₃₆O₄

C₂₃H₃₂O₄