(4-Benzyl-Morpholin-3-yl)-acetonitrile

Base Information

• Chemical Name: (4-Benzyl-Morpholin-3-yl)-acetonitrile
• CAS No.: 111949-90-7
• Molecular Formula: C₁₃H₁₆N₂O
• Molecular Weight: 216.283
• Mol file: 111949-90-7.mol

Synonyms:4-benzyl-3-chloro-phenol;4-benzyl-3-cyanomethylmorpholine;4-Benzyl-3-chlor-phenol;

Chemical Property of (4-Benzyl-Morpholin-3-yl)-acetonitrile

Chemical Property:

• PSA: 36.26000
• LogP: 1.73898

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-Benzyl-Morpholin-3-yl)-acetonitrile

There total 3 articles about (4-Benzyl-Morpholin-3-yl)-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

sodium cyanide (143-33-9,25596-52-5) + N-benzyl-3-(chloromethyl)morpholine (110167-16-3) → (4-benzylmorpholin-3-yl)acetonitrile (111949-90-7,1217855-96-3,170701-93-6)

Guidance literature:

In dimethyl sulfoxide; at 70 ℃; for 3.5h;

Reference yield:

4-benzyl-3-chloromethylmorpholine hydrochloride (114368-08-0) → (4-benzylmorpholin-3-yl)acetonitrile (111949-90-7,1217855-96-3,170701-93-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sat. NaHCO₃

2: 58 percent / dimethylsulfoxide / 3.5 h / 70 °C

With sodium hydrogencarbonate; In dimethyl sulfoxide;

Reference yield:

4-benzyl-3-(hydroxymethyl)morpholine (110167-20-9) → (4-benzylmorpholin-3-yl)acetonitrile (111949-90-7,1217855-96-3,170701-93-6)

Guidance literature:

Multi-step reaction with 3 steps

1: thionylchloride, DMF / CH₂Cl₂ / 2 h / Heating

2: sat. NaHCO₃

3: 58 percent / dimethylsulfoxide / 3.5 h / 70 °C

With thionyl chloride; sodium hydrogencarbonate; N,N-dimethyl-formamide; In dichloromethane; dimethyl sulfoxide;

upstream raw materials:

sodium cyanide

N-benzyl-3-(chloromethyl)morpholine

4-benzyl-3-chloromethylmorpholine hydrochloride

4-benzyl-3-(hydroxymethyl)morpholine

Downstream raw materials:

4-benzylmorpholin-3-ylacetic acid hydrochloride

N-<2-(4-benzylmorpholin-3yl)ethyl>acetamide