Methyl 6-chloro-5-(trifluoroMethyl)picolinate

Base Information

• Chemical Name: Methyl 6-chloro-5-(trifluoroMethyl)picolinate
• CAS No.: 1211518-35-2
• Molecular Formula: C8H5ClF3NO2
• Molecular Weight: 239.581
• Mol file: 1211518-35-2.mol

Synonyms:Methyl 6-chloro-5-(trifluoroMethyl)picolinate;6-Chloro-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester

Chemical Property of Methyl 6-chloro-5-(trifluoroMethyl)picolinate

Chemical Property:

• Boiling Point: 299.8±40.0 °C(Predicted)
• PKA: -3.45±0.10(Predicted)
• PSA: 39.19000
• Density: 1.443±0.06 g/cm3(Predicted)
• LogP: 2.54040
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Methyl6-chloro-5-(trifluoromethyl)picolinate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 6-Chloro-5-(trifluoromethyl)picolinate is used in preparation of pyridine amides as cannabinoid CB2 receptor agonists.

Technology Process of Methyl 6-chloro-5-(trifluoroMethyl)picolinate

There total 3 articles about Methyl 6-chloro-5-(trifluoroMethyl)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-oxy-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (1415899-18-1) → 6-chloro-5-(trifluoromethyl)-pyridine-2-carboxylic acid methyl ester (1211518-35-2)

Guidance literature:

With trichlorophosphate; at 0 - 50 ℃;

Reference yield:

5-(trifluoromethyl)-pyridine-2-carboxylic acid methyl ester (124236-37-9) → 6-chloro-5-(trifluoromethyl)-pyridine-2-carboxylic acid methyl ester (1211518-35-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / Reflux

2: trichlorophosphate / 0 - 50 °C

With 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In dichloromethane;

Reference yield:

5-(trifluoromethyl)picolinic acid (80194-69-0) → 6-chloro-5-(trifluoromethyl)-pyridine-2-carboxylic acid methyl ester (1211518-35-2)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / Reflux

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / Reflux

3: trichlorophosphate / 0 - 50 °C

With thionyl chloride; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In dichloromethane;

upstream raw materials:

5-(trifluoromethyl)picolinic acid

5-(trifluoromethyl)-pyridine-2-carboxylic acid methyl ester

1-oxy-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester

Refernces

• 1、 -. "NOVEL PYRIDINE DERIVATIVES". . . Retrieved 2014/06/24.
• 2、 -. "PYRIDIN- 2 -AMIDES USEFUL AS CB2 AGONISTS". . . Retrieved 2013/02/27.