Technology Process of 3-Pyridinepropanoic acid, 5-bromo-4-cyano-2-methoxy-, methyl ester
There total 5 articles about 3-Pyridinepropanoic acid, 5-bromo-4-cyano-2-methoxy-, methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bromine; sodium acetate; acetic acid;
at 20 ℃;
for 24h;
DOI:10.1021/jo060935j
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 92 percent / methanol / 16 h / 20 °C
2: 95 percent / triethylamine / tetrakis(triphenylphosphine)palladium / dimethylformamide / 36 h / 100 °C
3: 91 percent / hydrogen / palladium on carbon / methanol / 3 h / 20 °C / atmospheric pressure
4: 85 percent / sodium acetate; glacial acetic acid; bromine / 24 h / 20 °C
With
hydrogen; bromine; sodium acetate; acetic acid; triethylamine;
palladium on activated charcoal; tetrakis(triphenylphosphine) palladium(0);
In
methanol; N,N-dimethyl-formamide;
2: Heck coupling;
DOI:10.1021/jo060935j
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95 percent / triethylamine / tetrakis(triphenylphosphine)palladium / dimethylformamide / 36 h / 100 °C
2: 91 percent / hydrogen / palladium on carbon / methanol / 3 h / 20 °C / atmospheric pressure
3: 85 percent / sodium acetate; glacial acetic acid; bromine / 24 h / 20 °C
With
hydrogen; bromine; sodium acetate; acetic acid; triethylamine;
palladium on activated charcoal; tetrakis(triphenylphosphine) palladium(0);
In
methanol; N,N-dimethyl-formamide;
1: Heck coupling;
DOI:10.1021/jo060935j
