2-(5-chloropyridin-2-yl)acetic acid

Base Information

• Chemical Name: 2-(5-chloropyridin-2-yl)acetic acid
• CAS No.: 1000522-43-9
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.583
• Hs Code.: 2933399990
• Mol file: 1000522-43-9.mol

Synonyms:2-(5-chloropyridin-2-yl)acetic acid;RARECHEM AL MS 0475;5-Chloropyridine-2-acetic acid

Chemical Property of 2-(5-chloropyridin-2-yl)acetic acid

Chemical Property:

• Boiling Point: 295.9±25.0 °C(Predicted)
• PKA: 3.81±0.10(Predicted)
• PSA: 50.19000
• Density: 1.405±0.06 g/cm3(Predicted)
• LogP: 1.36210
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%, ^*data from raw suppliers

2-(5-Chloropyridin-2-yl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: 2-(5-Chloropyridin-2-yl)acetic acid is a chemical compound with versatile applications in various fields. In the realm of agrochemistry and crop protection, it can serve as a key intermediate in the synthesis of agrochemicals, pesticides, and herbicides. Its role is crucial in developing compounds that help control pests, weeds, and diseases, contributing to improved agricultural yields and food security. Additionally, in the pharmaceutical and medicinal chemistry field, this compound can be utilized in the development of potential drug candidates, particularly in the design of new medications for various diseases. Its significance varies within these fields, but it consistently plays a pivotal role in advancing agriculture and pharmaceutical research, with potential benefits for both crop production and human health.

Technology Process of 2-(5-chloropyridin-2-yl)acetic acid

There total 1 articles about 2-(5-chloropyridin-2-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

→ 2-(5-chloropyridin-2-yl)acetic acid (1000522-43-9)

Guidance literature:

Reference yield: 43.0%

2-(5-chloropyridin-2-yl)acetic acid (1000522-43-9) + 5-(2,6-dimethoxyphenyl)-6-(ethoxymethyl)-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carbohydrazide → 3-(5-((5-chloropyridin-2-yl)methyl)-1,3,4-oxadiazol-2-yl)-5-(2,6-dimethoxyphenyl)-6-(ethoxymethyl)-4-hydroxypyridin-2(1H)-one

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In 1,4-dioxane; ethyl acetate; at 100 ℃; for 24h;

DOI:10.1021/acs.jmedchem.0c01878

Reference yield:

1,3-bis(N-benzyloxycarbonyl)-3′-dihyro-3′-deoxy-3′(R)-amino spectinomycin + 2-(5-chloropyridin-2-yl)acetic acid (1000522-43-9) → C37H43ClN4O11

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

DOI:10.1021/acsinfecdis.6b00158

Downstream raw materials:

PF-06273340

Refernces

• 1、 -. "PYRROLO[2,3-d]PYRIMIDINE TROPOMYSIN-RELATED KINASE INHIBITORS". Page/Page column 94. . Retrieved 2012/10/18.