CyclopropanecarboxaMide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[2-[1,1-diMethyl-2-(phenylMethoxy)ethyl]-6-fluoro-1-[(2R)-2-hydroxy-3-(phenylMethoxy)propyl]-1H-indol-5-yl]-

Base Information

Chemical Name:CyclopropanecarboxaMide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[2-[1,1-diMethyl-2-(phenylMethoxy)ethyl]-6-fluoro-1-[(2R)-2-hydroxy-3-(phenylMethoxy)propyl]-1H-indol-5-yl]-
CAS No.:1294504-68-9
Molecular Formula:C40H39F3N2O6
Molecular Weight:700.755
Hs Code.:
Mol file:1294504-68-9.mol

CyclopropanecarboxaMide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[2-[1,1-diMethyl-2-(phenylMethoxy)ethyl]-6-fluoro-1-[(2R)-2-hydroxy-3-(phenylMethoxy)propyl]-1H-indol-5-yl]-

Synonyms:CyclopropanecarboxaMide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[2-[1,1-diMethyl-2-(phenylMethoxy)ethyl]-6-fluoro-1-[(2R)-2-hydroxy-3-(phenylMethoxy)propyl]-1H-indol-5-yl]-;CyclopropanecarboxaMide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[2-[1,1-diMethyl-2-(phenylMethoxy)ethyl]-6-fluoro-1-[(2R)-2-hydroxy-3-(phenylMethoxy)propyl]-1H-indol-5-yl]-9

Suppliers and Price of CyclopropanecarboxaMide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[2-[1,1-diMethyl-2-(phenylMethoxy)ethyl]-6-fluoro-1-[(2R)-2-hydroxy-3-(phenylMethoxy)propyl]-1H-indol-5-yl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
Cyclopropanecarboxamide,1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[2-[1,1-dimethyl-2-(phenylmethoxy)ethyl]-6-fluoro-1-[(2R)-2-hydroxy-3-(phenylmethoxy)propyl]-1H-indol-5-yl]-
500mg
$ 2000.00

Chemenu
(R)-N-(1-(3-(benzyloxy)-2-hydroxypropyl)-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-5-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide 95%+
250mg
$ 1404.00

Chemenu
(R)-N-(1-(3-(benzyloxy)-2-hydroxypropyl)-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-5-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide 95%+
100mg
$ 912.00

Total 8 raw suppliers

Chemical Property of CyclopropanecarboxaMide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[2-[1,1-diMethyl-2-(phenylMethoxy)ethyl]-6-fluoro-1-[(2R)-2-hydroxy-3-(phenylMethoxy)propyl]-1H-indol-5-yl]-

Chemical Property:

PSA：91.18000
LogP:7.91730

Purity/Quality:

NLT 98% ^*data from raw suppliers

Cyclopropanecarboxamide,1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[2-[1,1-dimethyl-2-(phenylmethoxy)ethyl]-6-fluoro-1-[(2R)-2-hydroxy-3-(phenylmethoxy)propyl]-1H-indol-5-yl]- ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of CyclopropanecarboxaMide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[2-[1,1-diMethyl-2-(phenylMethoxy)ethyl]-6-fluoro-1-[(2R)-2-hydroxy-3-(phenylMethoxy)propyl]-1H-indol-5-yl]-

There total 29 articles about CyclopropanecarboxaMide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[2-[1,1-diMethyl-2-(phenylMethoxy)ethyl]-6-fluoro-1-[(2R)-2-hydroxy-3-(phenylMethoxy)propyl]-1H-indol-5-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5272-33-3
2-methyl-4-(trimethylsilyl)but-3-yn-2-ol

: 1294504-68-9
N-{1-[(2R)-3-(benzyloxy)-2-hydroxypropyl]-2-[1-(benzyloxy)-2-methylpropan-2-yl]-6-fluoro-1H-indol-5-yl}-1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / water / 16 h

2.1: magnesium / tetrahydrofuran / 3.5 h / Inert atmosphere

2.2: 16 h / 25 °C

3.1: potassium hydroxide / methanol / 25 °C

4.1: palladium diacetate; potassium carbonate; 1,4-di(diphenylphosphino)-butane / acetonitrile / 1 h / Inert atmosphere; Large scale

4.2: 16 h / 80 °C / Large scale

5.1: dichloro bis(acetonitrile) palladium(II) / acetonitrile / 20 - 80 °C / Inert atmosphere; Large scale

6.1: triethylamine / dichloromethane / 0 - 20 °C

With hydrogenchloride; dichloro bis(acetonitrile) palladium(II); palladium diacetate; potassium carbonate; magnesium; triethylamine; 1,4-di(diphenylphosphino)-butane; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;

Reference yield:

: 1004294-65-8
1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane carboxylic acid chloride

: 1294504-67-8
(2R)-1-{5-amino-2-[1-(benzyloxy)-2-methylpropan-2-yl]-6-fluoro-1H-indol-1-yl}-3-(benzyloxy)propan-2-ol

: 1294504-68-9
N-{1-[(2R)-3-(benzyloxy)-2-hydroxypropyl]-2-[1-(benzyloxy)-2-methylpropan-2-yl]-6-fluoro-1H-indol-5-yl}-1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 862574-88-7
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid

: 1294504-67-8
(2R)-1-{5-amino-2-[1-(benzyloxy)-2-methylpropan-2-yl]-6-fluoro-1H-indol-1-yl}-3-(benzyloxy)propan-2-ol

: 1294504-68-9
N-{1-[(2R)-3-(benzyloxy)-2-hydroxypropyl]-2-[1-(benzyloxy)-2-methylpropan-2-yl]-6-fluoro-1H-indol-5-yl}-1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carboxamide

Guidance literature:: 1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid; With thionyl chloride; In toluene; at 60 ℃; for 2h;

(2R)-1-{5-amino-2-[1-(benzyloxy)-2-methylpropan-2-yl]-6-fluoro-1H-indol-1-yl}-3-(benzyloxy)propan-2-ol; With triethylamine; In dichloromethane; toluene;