(S,S)-N-Boc-2,5-dimethylpyrrolidine

Base Information

• Chemical Name: (S,S)-N-Boc-2,5-dimethylpyrrolidine
• CAS No.: 156038-84-5
• Molecular Formula: C11H21NO2
• Molecular Weight: 199.29
• Mol file: 156038-84-5.mol

Synonyms:(S,S)-N-Boc-2,5-dimethylpyrrolidine

Chemical Property of (S,S)-N-Boc-2,5-dimethylpyrrolidine

Chemical Property:

• Refractive Index: n20/D 1.444
• Flash Point: 86 °C
• PSA: 29.54000
• Density: 0.930 g/mL at 25 °C
• LogP: 2.73220

Purity/Quality:

99.3% ^*data from raw suppliers

(S,S)-N-BOC-2,5-DIMETHYLPYRROLIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T,N
• Statements: 25-50
• Safety Statements: 45-61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S,S)-N-Boc-2,5-dimethylpyrrolidine

There total 1 articles about (S,S)-N-Boc-2,5-dimethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl sulfate (77-78-1) + 2-methylpyrrolidine-1-carboxylic acid tert-butyl ester (137496-71-0) → (2S,5R)-2,5-Dimethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (92012-42-5) + (2S,5S)-2,5-Dimethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (156038-84-5)

Guidance literature:

With sec.-butyllithium; (-)-sparteine; Yield given. Multistep reaction. Yields of byproduct given; 1.) Et₂O, -78 deg C, 6 h, 2.) Et₂O, from -78 deg C to RT, overnight;

DOI:10.1021/ja00087a008

Reference yield:

(2S,5S)-2,5-Dimethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (156038-84-5) → (S,S)-2,5-dimethyl-N-(3,5-dinitrobenzoyl)pyrrolidine

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / TFA / CH₂Cl₂ / 4 h / Ambient temperature

2: 69 percent / Et₃N / tetrahydrofuran / 2 h / Ambient temperature

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja00087a008

upstream raw materials:

dimethyl sulfate

2-methylpyrrolidine-1-carboxylic acid tert-butyl ester

Refernces