2-[3-(Trifluoromethyl)phenyl]-3,4-dihydropyrimidin-4-one

Base Information

Chemical Name:2-[3-(Trifluoromethyl)phenyl]-3,4-dihydropyrimidin-4-one
CAS No.:125903-84-6
Molecular Formula:C11H7F3N2O
Molecular Weight:240.1812896
Hs Code.:
European Community (EC) Number:696-250-9
DSSTox Substance ID:DTXSID40562970
Wikidata:Q82447307
Mol file:125903-84-6.mol

Synonyms:125903-84-6;2-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrimidin-4-one;2-(3-(Trifluoromethyl)phenyl)pyrimidin-4(3H)-one;2-[3-(trifluoromethyl)phenyl]-1H-pyrimidin-6-one;2-[3-(Trifluoromethyl)phenyl]pyrimidin-4(3H)-one;DTXSID40562970;LZFFMRSTLMMQPT-UHFFFAOYSA-N;MFCD12107651;AKOS009844059;AKOS015942121;EG-0091;SB58607;CS-0358568;2-(3-(Trifluoromethyl)phenyl)pyrimidin-4-ol;4-Hydroxy-2-(3-trifluoromethylphenyl)pyrimidine

Suppliers and Price of 2-[3-(Trifluoromethyl)phenyl]-3,4-dihydropyrimidin-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-[3-(Trifluoromethyl)phenyl]-3,4-dihydropyrimidin-4-one

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:240.05104734
Heavy Atom Count:17
Complexity:373

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC(=C1)C(F)(F)F)C2=NC=CC(=O)N2

Technology Process of 2-[3-(Trifluoromethyl)phenyl]-3,4-dihydropyrimidin-4-one

There total 1 articles about 2-[3-(Trifluoromethyl)phenyl]-3,4-dihydropyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1590359-13-9
C₁₂H₉F₃N₂O

: 125903-84-6
C₁₁H₇F₃N₂O

Guidance literature:: With hydrogenchloride; In water;
DOI:10.1039/c3ta14876a

Reference yield: 93.0%

: 125903-84-6
2-<3-(trifluoromethyl)phenyl>pyrimidinone

: 125904-01-0
4-chloro-2-<3-(trifluoromethyl)phenyl>pyrimidine

Guidance literature:: With trichlorophosphate; for 3h; Heating;
DOI:10.1021/jm00166a023

Reference yield:

: 125903-84-6
2-<3-(trifluoromethyl)phenyl>pyrimidinone

: 125927-04-0
2-<3-(trifluoromethyl)phenyl>-4-pyrimidinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / POCl₃ / 3 h / Heating

2: 96 percent / NH₃ / ethanol / 10 h / 142 - 169 °C

With ammonia; trichlorophosphate; In ethanol;
DOI:10.1021/jm00166a023