alpha-aMine-oMega-propionic acid triethylene glycol

Base Information

• Chemical Name: alpha-aMine-oMega-propionic acid triethylene glycol
• CAS No.: 784105-33-5
• Molecular Formula: C₉H₁₉NO₅
• Molecular Weight: 221.254
• Hs Code.: 2942000090
• Mol file: 784105-33-5.mol

Synonyms:alpha-aMine-oMega-propionic acid triethylene glycol;H2N-PEG3-CH2CH2COOH;3-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)propanoic acid;α-AMine-ω-propionic acid triethylene glycol;NH2-PEG3-COOH;Amino-PEG3-propionic acid;H2N-PEG3-CH2CH2COOH

Chemical Property of alpha-aMine-oMega-propionic acid triethylene glycol

Chemical Property:

• Boiling Point: 372.1±32.0 °C(Predicted)
• PKA: 4.27±0.10(Predicted)
• PSA: 91.01000
• Density: 1.137±0.06 g/cm3(Predicted)
• LogP: 0.16990
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

3-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Amino-PEG3-acid is a PEG reagent containing an amino (NH2) and a terminal carboxylic acid group. The hydrophilic PEG unit increases hydrophilicity. NH2 amine group is reactive with carboxylic acids in the presence of coupling reagent such as EDC , or directly with NHS esters, to form a stable amide bond.
• Uses: 3-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)propanoic Acid is a building block that has been used as a reactant for the preparation of a MUC1-glycopeptide-BSA conjugate vaccine bearing (deoxy)(fluoro)-Thomsen-Friedenreich antigen.

Technology Process of alpha-aMine-oMega-propionic acid triethylene glycol

There total 3 articles about alpha-aMine-oMega-propionic acid triethylene glycol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate (252881-74-6,872340-65-3) → 3-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}propanoic acid (784105-33-5)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 3h; Large scale;

Reference yield:

C27H39NO5 → 3-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}propanoic acid (784105-33-5)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol / 12 h / 50 °C / 1500.15 Torr / Autoclave; Large scale

2: hydrogenchloride / water / 3 h / 20 °C / Large scale

With hydrogenchloride; palladium on activated charcoal; hydrogen; In methanol; water;

Reference yield:

8-dibenzylamino-3,6-dioxaoctan-1-ol (1349193-22-1) → 3-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}propanoic acid (784105-33-5)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane; water / 0 - 20 °C / Large scale

2: palladium on activated charcoal; hydrogen / methanol / 12 h / 50 °C / 1500.15 Torr / Autoclave; Large scale

3: hydrogenchloride / water / 3 h / 20 °C / Large scale

With hydrogenchloride; palladium on activated charcoal; tetrabutylammomium bromide; hydrogen; sodium hydroxide; In methanol; dichloromethane; water;

upstream raw materials:

tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate

8-dibenzylamino-3,6-dioxaoctan-1-ol

Downstream raw materials:

C₁₆H₂₄N₂O₈

benzyl 3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)propanoate