2-({1-[(Tert-butoxy)carbonyl]piperidin-4-yl}methyl)benzoic acid

Base Information

Chemical Name:2-({1-[(Tert-butoxy)carbonyl]piperidin-4-yl}methyl)benzoic acid
CAS No.:910442-78-3
Molecular Formula:C₁₈H₂₅NO₄
Molecular Weight:319.401
Hs Code.:

Synonyms:910442-78-3;2-({1-[(tert-butoxy)carbonyl]piperidin-4-yl}methyl)benzoic acid;4-(2-Carboxy-benzyl)-piperidine-1-carboxylic acid tert-butyl ester;2-[[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]methyl]benzoic acid;SCHEMBL3881471;PXNRVRXPLIHZEN-UHFFFAOYSA-N;AKOS033771901;CS-0239560;FT-0718159;EN300-215297;Z2049713139;2-({1-[(tert-butoxy)carbonyl]piperidin-4-yl}methyl)benzoicacid

Suppliers and Price of 2-({1-[(Tert-butoxy)carbonyl]piperidin-4-yl}methyl)benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-({1-[(Tert-butoxy)carbonyl]piperidin-4-yl}methyl)benzoic acid

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:319.17835828
Heavy Atom Count:23
Complexity:421

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)CC2=CC=CC=C2C(=O)O

Technology Process of 2-({1-[(Tert-butoxy)carbonyl]piperidin-4-yl}methyl)benzoic acid

There total 5 articles about 2-({1-[(Tert-butoxy)carbonyl]piperidin-4-yl}methyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1445804-12-5
4-(2-methoxycarbonyl-benzyl)-piperidine-1-carboxylic acid tert-butyl ester

: 910442-78-3
4-(2-carboxy-benzyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: 4-(2-methoxycarbonyl-benzyl)-piperidine-1-carboxylic acid tert-butyl ester; With sodium hydroxide; In ethanol; at 60 ℃; for 16h;

With hydrogenchloride; In ethanol; water;

Reference yield:

: C₂₀H₂₉NO₄

: 910442-78-3
4-(2-carboxy-benzyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: C₂₀H₂₉NO₄; With sodium hydroxide; water; In methanol; at 50 ℃; for 2h;

With hydrogenchloride; In methanol; water; at 0 ℃;

Reference yield:

: 216368-49-9
2-(diethoxy-phosphorylmethyl)-benzoic acid methyl ester

: 910442-78-3
4-(2-carboxy-benzyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride; 15-crown-5 / tetrahydrofuran / 0.5 h / 0 - 20 °C

1.2: 48 h / 0 - 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 3 h / 20 °C / 7500.75 Torr

3.1: sodium hydroxide / ethanol / 16 h / 60 °C

With 15-crown-5; palladium 10% on activated carbon; hydrogen; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol;