4-Ethyl-1-naphthaleneMethanol

Base Information

• Chemical Name: 4-Ethyl-1-naphthaleneMethanol
• CAS No.: 108368-96-3
• Molecular Formula: C13H14O
• Molecular Weight: 186.254
• Mol file: 108368-96-3.mol

Synonyms:4-Ethyl-1-naphthaleneMethanol

Chemical Property of 4-Ethyl-1-naphthaleneMethanol

Chemical Property:

• PSA: 20.23000
• LogP: 2.89450

Purity/Quality:

98%min ^*data from raw suppliers

(4-Ethylnaphthalen-1-yl)methanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Ethyl-1-naphthaleneMethanol

There total 9 articles about 4-Ethyl-1-naphthaleneMethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

ethyl 4-ethyl-1-naphthoate → (4-ethylnaphthalen-1-yl)methanol (108368-96-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2017.06.030

Reference yield:

4-ethyl-1-naphthalenecarboxylic acid (91902-58-8) → (4-ethylnaphthalen-1-yl)methanol (108368-96-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1039/d1cc05609c

Reference yield:

4-carboethoxy-1-methylnaphthalene (51934-45-3) → (4-ethylnaphthalen-1-yl)methanol (108368-96-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / acetonitrile / 16 h / Reflux

2.1: magnesium / diethyl ether / 35 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; lithium aluminium tetrahydride; magnesium; dibenzoyl peroxide; In tetrahydrofuran; diethyl ether; acetonitrile;

DOI:10.1016/j.bmc.2017.06.030

upstream raw materials:

acetic acid-(4-ethyl-[1]naphthylmethyl ester)

1-methyl-4-ethylnaphthalene

1-ethylnapthelene

1-ethyl-4-chloromethyl-naphthalene

Downstream raw materials:

4-ethyl-1-naphthalenecarboxylic acid

Refernces

• 1、 Boldrini, Cosimo,Harutyunyan, Syuzanna R.. "Pd-catalyzed allylative dearomatisation using Grignard reagents". supporting information. p. 11807 - 11810. Retrieved 2021/11/30.