3-[(4-fluorobenzyl)thio]-1-propanamine(SALTDATA: FREE)

Base Information

• Chemical Name: 3-[(4-fluorobenzyl)thio]-1-propanamine(SALTDATA: FREE)
• CAS No.: 933758-12-4
• Molecular Formula: C₁₀H₁₄FNS
• Molecular Weight: 199.292
• Mol file: 933758-12-4.mol

Synonyms:3-[(4-fluorobenzyl)thio]-1-propanamine(SALTDATA: FREE)

Chemical Property of 3-[(4-fluorobenzyl)thio]-1-propanamine(SALTDATA: FREE)

Chemical Property:

• Vapor Pressure: 0.00165mmHg at 25°C
• Boiling Point: 294.2°C at 760 mmHg
• Flash Point: 131.7°C
• PSA: 51.32000
• Density: 1.125g/cm³
• LogP: 3.10800

Purity/Quality:

98% ^*data from raw suppliers

3-[(4-fluorobenzyl)thio]-1-propanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[(4-fluorobenzyl)thio]-1-propanamine(SALTDATA: FREE)

There total 1 articles about 3-[(4-fluorobenzyl)thio]-1-propanamine(SALTDATA: FREE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-fluorophenyl)methanethiol (15894-04-9) + 3-bromopropan-1-amine hydrochloride (41236-20-8) → C10H14FNS (933758-12-4)

Guidance literature:

With lithium hydroxide; In methanol; water; at 20 ℃; for 2h;

DOI:10.1002/anie.201711277

Reference yield:

C10H14FNS (933758-12-4) → C17H18FNO2S2

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / chloroform; water / 2 h / 20 °C

2: 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate; sodium phosphate; C₈₄H₁₁₃O₄P / toluene / 48 h / 0 °C

With C₈₄H₁₁₃O₄P; sodium phosphate; sodium hydroxide; 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate; In chloroform; water; toluene;

DOI:10.1002/anie.201711277

upstream raw materials:

(4-fluorophenyl)methanethiol

3-bromopropan-1-amine hydrochloride

Refernces