Ethyl 4-naphthalen-1-yl-1H-pyrrole-3-carboxylate

Base Information

Chemical Name:Ethyl 4-naphthalen-1-yl-1H-pyrrole-3-carboxylate
CAS No.:226930-26-3
Molecular Formula:C₁₇H₁₅NO₂
Molecular Weight:265.312
Hs Code.:
DSSTox Substance ID:DTXSID50433162
Wikidata:Q82247288
Mol file:226930-26-3.mol

Synonyms:Ethyl 4-naphthalen-1-yl-1H-pyrrole-3-carboxylate;226930-26-3;AGN-PC-0MW2M5;SCHEMBL6598620;DTXSID50433162;RPMKLIJEJHONCN-UHFFFAOYSA-N;3-ethoxycarbonyl-4-(naphthalen-1-yl)-1h-pyrrole;3-(ethoxycarbonyl)-4-(naphthalen-1-yl)-1h-pyrrole;ethyl 4-(naphthalen-1-yl)-1h-pyrrole-3-carboxylate

Suppliers and Price of Ethyl 4-naphthalen-1-yl-1H-pyrrole-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Ethyl 4-naphthalen-1-yl-1H-pyrrole-3-carboxylate

Chemical Property:

PSA：42.09000
LogP:4.01160
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:265.110278721
Heavy Atom Count:20
Complexity:344

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CNC=C1C2=CC=CC3=CC=CC=C32

Technology Process of Ethyl 4-naphthalen-1-yl-1H-pyrrole-3-carboxylate

There total 4 articles about Ethyl 4-naphthalen-1-yl-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.5%

: 38622-91-2,36635-61-7
[(p-methylphenyl)sulfonylmethyl]isonitrile

: 98978-43-9
(E)-ethyl 3-(naphthalen-1-yl)acrylate

: 226930-26-3
ethyl 4-(1-naphthyl)-1H-pyrrole-3-carboxylate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran;
DOI:10.1016/S0960-894X(01)00624-2

Reference yield:

: 38622-91-2,36635-61-7
[(p-methylphenyl)sulfonylmethyl]isonitrile

: 98978-43-9,13979-14-1
ethyl 3-(naphthalen-1-yl)acrylate

: 226930-26-3
ethyl 4-(1-naphthyl)-1H-pyrrole-3-carboxylate

Guidance literature:: With sodium tert-pentoxide; In toluene; at 0 - 20 ℃; for 5h; Reagent/catalyst; Solvent; Large scale; Green chemistry;
DOI:10.1021/op7002826

Reference yield:

: 66-77-3
1-naphthaldehyde

: 226930-26-3
ethyl 4-(1-naphthyl)-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tert-pentoxide / 1 h / 0 - 20 °C / Large scale; Green chemistry

2: sodium tert-pentoxide / toluene / 5 h / 0 - 20 °C / Large scale; Green chemistry

With sodium tert-pentoxide; In toluene; 1: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/op7002826