(1r,3r,5r,7r)-2-oxa-6-azaadaMantane

Base Information

• Chemical Name: (1r,3r,5r,7r)-2-oxa-6-azaadaMantane
• CAS No.: 19557-29-0
• Molecular Formula: C8H13NO
• Molecular Weight: 139.19492
• Hs Code.: 2904200090
• Mol file: 19557-29-0.mol

Synonyms:(1r,3r,5r,7r)-2-oxa-6-azaadaMantane;(1r,3s,5R,7S)-2-Oxa-6-azaadaMantane;2-Oxa-6-azaadamantane

Chemical Property of (1r,3r,5r,7r)-2-oxa-6-azaadaMantane

Chemical Property:

• PSA: 21.26000
• LogP: 0.99700
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

(1r,3r,5r,7r)-2-Oxa-6-azaadamantane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1r,3r,5r,7r)-2-oxa-6-azaadaMantane

There total 11 articles about (1r,3r,5r,7r)-2-oxa-6-azaadaMantane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-p-toluenesulfonyl-6-oxa-2-azaadamantane (35986-02-8) → 6-aza-2-oxaadamantane (19557-29-0)

Guidance literature:

With naphthalene; sodium; In 1,2-dimethoxyethane; at -50 ℃; Inert atmosphere;

DOI:10.1021/jm100390h

Reference yield:

4,8-dibromo-6-(toluene-4-sulfonyl)-2-oxa-6-aza-adamantane (35985-99-0,35986-00-6) → 2-Aza-6-oxaadamantan (19557-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, NaOH / Raney-Ni / ethanol

2: Na / liquid ammonia

With sodium hydroxide; hydrogen; sodium; nickel; In ethanol; ammonia;

DOI:10.1016/S0040-4039(01)84443-9

Reference yield:

9-(toluene-4-sulfonyl)-9-aza-bicyclo[3.3.1]nona-2,6-diene (35985-98-9) → 2-Aza-6-oxaadamantan (19557-29-0)

Guidance literature:

Multi-step reaction with 3 steps

1: NBS / tetrahydrofuran; H₂O

2: H₂, NaOH / Raney-Ni / ethanol

3: Na / liquid ammonia

With sodium hydroxide; N-Bromosuccinimide; hydrogen; sodium; nickel; In tetrahydrofuran; ethanol; ammonia; water;

DOI:10.1016/S0040-4039(01)84443-9

upstream raw materials:

N-p-toluenesulfonyl-6-oxa-2-azaadamantane

6-benzenesulfonyl-2-oxa-6-aza-adamantane

6-(toluene-4-sulfonyl)-2-oxa-6-aza-adamantane

9-(toluene-4-sulfonyl)-9-aza-bicyclo[3.3.1]nona-2,6-diene

Downstream raw materials:

2-oxa-6-aza-adamantane-6-carboxylic acid ethyl ester

6-formyl-2-oxa-6-aza-adamantane