Dispiro[2.0.2.1]heptane-1-methanol, 5,5-difluoro-, (1R,3S,4R)- (9CI)

Base Information

Chemical Name:Dispiro[2.0.2.1]heptane-1-methanol, 5,5-difluoro-, (1R,3S,4R)- (9CI)
CAS No.:321857-33-4
Molecular Formula:C₈H₁₀F₂O
Molecular Weight:160.164
Hs Code.:
Mol file:321857-33-4.mol

Synonyms:Dispiro[2.0.2.1]heptane-1-methanol, 5,5-difluoro-, (1R,3S,4R)- (9CI)

Suppliers and Price of Dispiro[2.0.2.1]heptane-1-methanol, 5,5-difluoro-, (1R,3S,4R)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Dispiro[2.0.2.1]heptane-1-methanol, 5,5-difluoro-, (1R,3S,4R)- (9CI)

Chemical Property:

PSA：20.23000
LogP:1.41410

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Dispiro[2.0.2.1]heptane-1-methanol, 5,5-difluoro-, (1R,3S,4R)- (9CI)

There total 7 articles about Dispiro[2.0.2.1]heptane-1-methanol, 5,5-difluoro-, (1R,3S,4R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 2-((1R,3S)-5,5-Difluoro-dispiro[2.0.2.1]hept-1-ylmethoxy)-tetrahydro-pyran

: 321857-33-4
((1R,3S,4R)-5,5-Difluoro-dispiro[2.0.2.1]hept-1-yl)-methanol

: 321857-34-5
((1R,3S,4S)-5,5-Difluoro-dispiro[2.0.2.1]hept-1-yl)-methanol

Guidance literature:: With pyridinium p-toluenesulfonate; In methanol; Heating;

Reference yield:

: endo-4-methylenespiropent-1-ylmethanol

: 321857-33-4
((1R,3S,4R)-5,5-Difluoro-dispiro[2.0.2.1]hept-1-yl)-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: Lipase PS; AcOCH=CH₂ / diethyl ether / 20 °C

2: PPTS / CH₂Cl₂ / 20 °C

3: PPh₃; KF / 1,2-dimethoxy-ethane / 20 °C

4: PPTS / methanol / Heating

With potassium fluoride; vinyl acetate; Lipase PS; pyridinium p-toluenesulfonate; triphenylphosphine; In methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane;
DOI:10.1080/10587250108024994

Reference yield:

: 321857-32-3
(1R,3S)-4-methylenespiropent-1-ylmethanol

: 321857-33-4
((1R,3S,4R)-5,5-Difluoro-dispiro[2.0.2.1]hept-1-yl)-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: PPTS / CH₂Cl₂ / 20 °C

2: PPh₃; KF; 18-crown-6 / 1,2-dimethoxy-ethane / 6 h / 20 °C

3: 32 percent / PPTS / methanol / Heating

With potassium fluoride; 18-crown-6 ether; pyridinium p-toluenesulfonate; triphenylphosphine; In methanol; 1,2-dimethoxyethane; dichloromethane;