Chemical Property of Falnidamol
Chemical Property:
- Vapor Pressure:3.15E-12mmHg at 25°C
- Melting Point:>217°C (dec.)
- Boiling Point:594°Cat760mmHg
- PKA:8?+-.0.10(Predicted)
- Flash Point:313.1°C
- PSA：78.86000
- Density:g/cm3
- LogP:5.14990
- Storage Temp.:Desiccate at +4°C
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- XLogP3:3.4
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:4
- Exact Mass:387.1374495
- Heavy Atom Count:27
- Complexity:479
- Purity/Quality:
-
99%, *data from raw suppliers
BIBX 1382 dihydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CN1CCC(CC1)NC2=NC=C3C(=N2)C(=NC=N3)NC4=CC(=C(C=C4)F)Cl
- Recent ClinicalTrials:BIBX 1382 in Treating Patients With Solid Tumors
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Uses
Falnidamol is a novel ErbB receptor kinase inhibitor that is more potent at inhibiting signaling induced by TGF-α than that induced by neuregulin1-β1 or anti-ErbB2 agonist antibodies. BIBX 1382 Dihydrochloride, is a potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM).
