2-(2,5-Dioxo-pyrrolidin-1-yl)-ethanesulfonyl chloride

Base Information

• Chemical Name: 2-(2,5-Dioxo-pyrrolidin-1-yl)-ethanesulfonyl chloride
• CAS No.: 89756-66-1
• Molecular Formula: C6H8ClNO4S
• Molecular Weight: 225.653
• European Community (EC) Number: 833-387-7
• Mol file: 89756-66-1.mol

Synonyms:2-(2,5-Dioxo-pyrrolidin-1-yl)-ethanesulfonyl chloride;89756-66-1;2-(2,5-dioxopyrrolidin-1-yl)ethane-1-sulfonyl chloride;2-(2,5-dioxopyrrolidin-1-yl)ethanesulfonyl chloride;2-(2,5-Dioxo-pyrrolidin-1-yl)ethanesulfonyl chloride;2-(2,5-Dioxopyrrolidin-1-yl)-ethanesulfonyl chloride;SCHEMBL1411987;RELWRPQYLYNUPL-UHFFFAOYSA-N;BBL031013;STL373209;AKOS000303389;VS-10180;DB-345961;CS-0234491;EN300-142420;G28399;2-(2,5-dioxo-1-pyrrolidinyl)ethanesulfonyl chloride;2-(2,5-dioxopyrrolidin-1-yl)ethane-sulfonyl chloride;2-(2,5-Dioxo-pyrrolidin-1-yl)-ethane sulfonyl chloride;2-(2,5-dioxopyrrolidin-1-yl)ethane-1-sulfonylchloride

Chemical Property of 2-(2,5-Dioxo-pyrrolidin-1-yl)-ethanesulfonyl chloride

Chemical Property:

• PSA: 79.90000
• LogP: 0.72270
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 224.9862566
• Heavy Atom Count: 13
• Complexity: 315

Purity/Quality:

98%min ^*data from raw suppliers

2-(2,5-Dioxo-pyrrolidin-1-yl)-ethanesulfonylChloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

• Canonical SMILES: C1CC(=O)N(C1=O)CCS(=O)(=O)Cl

Technology Process of 2-(2,5-Dioxo-pyrrolidin-1-yl)-ethanesulfonyl chloride

There total 1 articles about 2-(2,5-Dioxo-pyrrolidin-1-yl)-ethanesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Potassium; 2-(2,5-dioxo-pyrrolidin-1-yl)-ethanesulfonate → 2-(2,5-dioxo-1-pyrrolidinyl)ethanesulfonyl chloride (89756-66-1)

Guidance literature:

With phosphorus pentachloride; In dichloromethane; Yield given; 15 - 20 deg C, 5 h, RT, 48 h;

DOI:10.1002/jps.2600730128

Reference yield: 17.0%

5-phenyl-3-(4-piperidinyl)-1H-indazole-7-carboxamide hydrochloride + 2-(2,5-dioxo-1-pyrrolidinyl)ethanesulfonyl chloride (89756-66-1) → 3-{1-[(2-aminoethyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indazole-7-carboxamide

Guidance literature:

5-phenyl-3-(4-piperidinyl)-1H-indazole-7-carboxamide hydrochloride; 2-(2,5-dioxo-1-pyrrolidinyl)ethanesulfonyl chloride; With dmap; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

With hydrazine; In N,N-dimethyl-formamide; for 4h;

Reference yield:

2-(2,5-dioxo-1-pyrrolidinyl)ethanesulfonyl chloride (89756-66-1) + benzylamine (100-46-9) → 2,5-dioxo-N-(phenylmethyl)-1-pirrolidineethanesulfonamide

Guidance literature:

With potassium carbonate; In dichloromethane; Yield given;

DOI:10.1002/jps.2600730128

Refernces