Ethyl 3-Methylpiperidine-3-carboxylate hydrochloride

Base Information

• Chemical Name: Ethyl 3-Methylpiperidine-3-carboxylate hydrochloride
• CAS No.: 176523-95-8
• Molecular Formula: C9H18ClNO2
• Molecular Weight: 207.7
• Hs Code.: 2933399090
• Mol file: 176523-95-8.mol

Synonyms:Ethyl 3-Methylpiperidine-3-carboxylate hydrochloride;3-Methyl-piperidine-3-carboxylic acid ethyl ester hydrochloride

Chemical Property of Ethyl 3-Methylpiperidine-3-carboxylate hydrochloride

Chemical Property:

• PSA: 38.33000
• LogP: 2.07000

Purity/Quality:

NLT 98% ^*data from raw suppliers

Ethyl3-methylpiperidine-3-carboxylatehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 3-Methylpiperidine-3-carboxylate hydrochloride

There total 2 articles about Ethyl 3-Methylpiperidine-3-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethyl N-t-butyloxycarbonyl-3-methylpiperidine-3-carboxylate (278789-43-8) → ethyl 3-methylpiperidine-3-carboxylate hydrochloride (176523-95-8,297176-81-9)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 3h;

Reference yield:

ethyl N-(t-butyloxycarbonyl)nipecotate (148672-74-6,130250-54-3) → ethyl 3-methylpiperidine-3-carboxylate hydrochloride (176523-95-8,297176-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 18 h / -78 - 20 °C

2: hydrogenchloride / ethyl acetate / 3 h / 20 °C

With hydrogenchloride; lithium hexamethyldisilazane; In tetrahydrofuran; ethyl acetate;

Reference yield: 88.0%

ethyl 3-methylpiperidine-3-carboxylate hydrochloride (176523-95-8,297176-81-9) + 7-chloro-2-(4-chlorophenyl)-5-methyl-6-(propan-2-yl)pyrazolo[1,5-a]pyrimidine → ethyl 1-[2-(4-chlorophenyl)-5-methyl-6-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-yl]-3-methylpiperidine-3-carboxylate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 120 ℃; for 20h;

upstream raw materials:

ethyl N-(t-butyloxycarbonyl)nipecotate

ethyl N-t-butyloxycarbonyl-3-methylpiperidine-3-carboxylate

Downstream raw materials:

3-methyl-1-(3-((5-methyl-2-phenyloxazol-4-yl)methoxy)benzyl)piperidine-3-carboxylic acid ethyl ester

Refernces

• 1、 -. "PHARMACOLOGICALLY ACTIVE ARYL-SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES". . . Retrieved 2018/10/19.