5'-O-(DIMETHOXYTRITYL)-N2-ETHYL-2'-DEOXYGUANOSINE

Base Information

Chemical Name:5'-O-(DIMETHOXYTRITYL)-N2-ETHYL-2'-DEOXYGUANOSINE
CAS No.:209785-64-8
Molecular Formula:C33H35N5O6
Molecular Weight:597.66
Hs Code.:
Mol file:209785-64-8.mol

Synonyms:5'-O-(DIMETHOXYTRITYL)-N2-ETHYL-2'-DEOXYGUANOSINE;5'-O-(DMT)-N2-ETHYL-2'-DEOXYGUANOSINE

Suppliers and Price of 5'-O-(DIMETHOXYTRITYL)-N2-ETHYL-2'-DEOXYGUANOSINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
5'-O-(DIMETHOXYTRITYL)-N2-ETHYL-2'-DEOXYGUANOSINE 95.00%
5MG
$ 501.71

Total 6 raw suppliers

Chemical Property of 5'-O-(DIMETHOXYTRITYL)-N2-ETHYL-2'-DEOXYGUANOSINE

Chemical Property:

PSA：132.75000
LogP:4.29870

Purity/Quality:

97% ^*data from raw suppliers

5'-O-(DIMETHOXYTRITYL)-N2-ETHYL-2'-DEOXYGUANOSINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 5’-O-(Dimethoxytrityl)-N2-ethyl-2’-deoxyguanosine is a derivative of 8-Oxo-2’-deoxyguanosine (O850250), which is a marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. It can induce differentiation of Friend murine erythroleukemia cells in vitro.

Technology Process of 5'-O-(DIMETHOXYTRITYL)-N2-ETHYL-2'-DEOXYGUANOSINE

There total 8 articles about 5'-O-(DIMETHOXYTRITYL)-N2-ETHYL-2'-DEOXYGUANOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 209785-65-9
N²-benzyl-O⁶-(2-(4-nitrophenyl)ethyl)-5′-(4,4′-dimethoxytrityl)-2′-deoxyguanosine

: 209785-64-8
2-Benzylamino-9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-1,9-dihydro-purin-6-one

Guidance literature:: With pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; for 15h; Ambient temperature;
DOI:10.1021/jm970434d

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 209785-64-8
2-Benzylamino-9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-1,9-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: 2.5 g / pyridine / 15 h / Ambient temperature

2: 84 percent / dimethylformamide / 24 h / Ambient temperature

3: 73 percent / DBU, pyridine / 15 h / Ambient temperature

With pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide;
DOI:10.1021/jm970434d

Reference yield:

: 961-07-9
2'-Deoxyguanosine

: 209785-64-8
2-Benzylamino-9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-1,9-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / pyridine / dimethylformamide / 4 h / 75 °C

2: 1.) PPh₃, 2.) DEAD / 1.) dioxane, 80 deg C, 30 min, 2.) dioxane, 60 deg C, 2 h

3: NH₃ / methanol / 15 h / Ambient temperature

4: HF, pyridine, t-BuONO / 2 h / -30 °C

5: 2.5 g / pyridine / 15 h / Ambient temperature

6: 84 percent / dimethylformamide / 24 h / Ambient temperature

7: 73 percent / DBU, pyridine / 15 h / Ambient temperature

With pyridine; tert.-butylnitrite; hydrogen fluoride; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; diethylazodicarboxylate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm970434d