1-(3-beta-AMino-2,3-dideoxy-beta-D-threopenta-furanosyl)thyMine

Base Information

• Chemical Name: 1-(3-beta-AMino-2,3-dideoxy-beta-D-threopenta-furanosyl)thyMine
• CAS No.: 73971-79-6
• Molecular Formula: C₁₀H₁₅N₃O₄
• Molecular Weight: 241.247
• Mol file: 73971-79-6.mol

Synonyms:1-(3-beta-AMino-2,3-dideoxy-beta-D-threopenta-furanosyl)thyMine;3'-beta-AMino-3'-deoxy thyMidine;1-(3-Amino-2,3-dideoxy-beta-D-threo-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

Chemical Property of 1-(3-beta-AMino-2,3-dideoxy-beta-D-threopenta-furanosyl)thyMine

Chemical Property:

• PSA: 110.34000
• LogP: -0.84760

Purity/Quality:

97% ^*data from raw suppliers

1-((2R,4R,5S)-4-Amino-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-beta-AMino-2,3-dideoxy-beta-D-threopenta-furanosyl)thyMine

There total 1 articles about 1-(3-beta-AMino-2,3-dideoxy-beta-D-threopenta-furanosyl)thyMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 1-((S)-4-Amino-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione (52450-18-7,73971-79-6,123191-39-9,127501-59-1,127501-60-4,137637-54-8)

Guidance literature:

Entspr. Azid, H2;

Reference yield: 93.2%

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + 1-(3-Amino-2,3-dideoxy-β-D-threo-pentofuranosyl)thymine (73971-79-6) → L-phenylalanyl-N1-[(2S,3R,5R)-tetrahydro-2-(hydroxymethyl)-5-(1,2,3,4-tetrahydro-5-methyl-2,4-dioxopyrimidin-1-yl)furan-3-yl]-L-phenylalaninamide

Guidance literature:

Multistep reaction;

DOI:10.1002/hlca.200390295

Reference yield: 81.8%

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + 1-(3-Amino-2,3-dideoxy-β-D-threo-pentofuranosyl)thymine (73971-79-6) → L-phenylalanyl-N1-[(2S,3R,5R)-tetrahydro-2-(hydroxymethyl)-5-(1,2,3,4-tetrahydro-5-methyl-2,4-dioxopyrimidin-1-yl)furan-3-yl]-L-leucinamide

Guidance literature:

Multistep reaction;

DOI:10.1002/hlca.200390295

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