4,5,6,7-Tetrahydro-5-azaindole

Base Information

• Chemical Name: 4,5,6,7-Tetrahydro-5-azaindole
• CAS No.: 1176405-02-9
• Molecular Formula: C7H10N2
• Molecular Weight: 122.1677
• Hs Code.: 2933990090
• Mol file: 1176405-02-9.mol

Synonyms:4,5,6,7-Tetrahydro-5-azaindole;4,5,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridine

Chemical Property of 4,5,6,7-Tetrahydro-5-azaindole

Chemical Property:

• Boiling Point: 286.0±30.0 °C(Predicted)
• PKA: 17.85±0.20(Predicted)
• PSA: 27.82000
• Density: 1.104±0.06 g/cm3(Predicted)
• LogP: 0.98920
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

4,5,6,7-Tetrahydro-5-azaindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5,6,7-Tetrahydro-5-azaindole

There total 1 articles about 4,5,6,7-Tetrahydro-5-azaindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-benzyl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine (272442-27-0) → 4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine (1176405-02-9)

Guidance literature:

With palladium on activated charcoal; hydrogen;

DOI:10.1016/j.bmcl.2013.05.054

Reference yield: 82.0%

di-tert-butyl dicarbonate (24424-99-5) + 4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine (1176405-02-9) → C12H18N2O2 (1414958-79-4)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 48h;

Reference yield: 48.0%

4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine (1176405-02-9) + 2-chloro-N-(3-methyl-2-phenylbutyl)quinazolin-4-amine → 2-(6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-N-(3-methyl-2-phenylbutyl)quinazolin-4-amine

Guidance literature:

In ethanol; Reflux;

upstream raw materials:

5-benzyl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine

Downstream raw materials:

C₁₂H₁₈N₂O₂